| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(1-methyl-1H-1,2,3-triazole-4-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
184000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 156 |
NA |
196000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-2-((1-(2-hydroxyacetyl)pyrrolidin-3-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
387000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 546 |
NA |
492000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 477 |
NA |
526000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 358 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-4-yl)oxy)-5-(4-((4-((S)-3-methyl-4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
120000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
4-((4-(3-cyano-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-1,3,5-triazin-2-yl)amino)-N-(oxetan-3-yl)benzamide |
NA |
899000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 161 |
NA |
173000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 547 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 220 |
NA |
222000|256000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 412 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 155 |
NA |
198000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 557 |
NA |
917000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 337 |
NA |
572000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((3-(2-Hydroxyacetyl)-3-azabicyclo[3.1.1]heptan-6-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 404 |
NA |
457000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(tetrahydro-2H-pyran-4-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
423000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((4S,5R)-5-fluoro-3,3-dimethyl-1-(1H-pyrazole-5-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
125000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 356 |
NA |
550000 |
NA |
NA |
NA |
NA |
BindingDB |