| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| JAK2 |
2-(((2S,4S,5R)-5-fluoro-1-(2-hydroxyacetyl)-2-methylpiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 548 |
NA |
353000|562000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 286 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((tetrahydro-2H-pyran-4-yl)oxy)-5-(4-((3,4,5-trimethoxyphenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
602000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((S)-3,3-difluoro-1-((R)-2-oxothiazolidine-4-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
177000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 510 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((1-(tert-butyl)-1H-pyrazol-4-yl)amino)-1,3,5-triazin-2-yl)-2-(((3R,4S)-3-fluoro-1-(5-methyl-4H-1,2,4-triazole-3-carbonyl)piperidin-4-yl)oxy)benzonitrile |
NA |
212000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 351 |
NA |
662000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 344 |
NA |
707000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 372 |
NA |
305000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 266 |
NA |
387000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-formylpiperidin-4-yl)oxy)-5-(4-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
274000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((2S,4S)-2-methyl-1-(1H-1,2,3-triazole-5-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
224000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(1H-imidazole-2-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
174000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 271 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(S)-2-((3,3-difluoro-1-(4H-1,2,4-triazole-3-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
104000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)methoxy)benzonitrile |
NA |
313000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-5-(4-((3-morpholinophenyl)amino)-1,3,5-triazin-2-yl)-2-(pyrrolidin-3-yloxy)benzonitrile |
NA |
641000 |
NA |
NA |
NA |
NA |
BindingDB |