| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| JAK2 |
US10040781, Example 28 |
NA |
583000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 176 |
NA |
133000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,5S)-1-(2-hydroxyacetyl)-5-methylpyrrolidin-3-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
525000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 427 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 516 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((5-fluoro-1-((S)-2-hydroxypropanoyl)-3,3-dimethylpiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
317000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 118 |
NA |
284000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(S)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-(1-(tetrahydro-2H-pyran-4-yl)ethoxy)benzonitrile |
NA |
219000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 617 |
NA |
226000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 501 |
NA |
457000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((4,4-Difluorocyclohexyl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
655000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 584 |
NA |
433000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 465 |
NA |
706000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 402 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 400 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((3-Fluorooxetan-3-yl)methoxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
110000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((1-(tert-butyl)-1H-pyrazol-4-yl)amino)-1,3,5-triazin-2-yl)-2-(((3R,4S)-1-((S)-2,3-dihydroxypropanoyl)-3-fluoropiperidin-4-yl)oxy)benzonitrile |
NA |
228000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 506 |
NA |
601000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((2S,4R)-4-hydroxy-5-oxopyrrolidine-2-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
858000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-1-(2-cyanopropanoyl)-3-fluoropiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
212000 |
NA |
NA |
NA |
NA |
BindingDB |