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Drugs And Genes
Negative Drug Target Genes
GENE_SYMBOL DRUG_NAME Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) Potency (nM) AC50 (nM) Datasource
JAK2 2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((4-((R)-1-(oxetan-3-yl)pyrrolidin-2-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile NA 1000000 NA NA NA NA BindingDB
JAK2 2-((5-Fluoro-1-(2-hydroxyacetyl)-3,3-dimethylpiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile NA 117000 NA NA NA NA BindingDB
JAK2 US10040781, Example 591 NA 658000 NA NA NA NA BindingDB
JAK2 (S)-4-(4-((4-(3-cyano-4-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)phenyl)-1,3,5-triazin-2-yl)amino)phenyl)morpholine-2-carboxamide NA 347000 NA NA NA NA BindingDB
JAK2 US10040781, Example 551 NA 799000 NA NA NA NA BindingDB
JAK2 US10040781, Example 543 NA 1000000 NA NA NA NA BindingDB
JAK2 2-(((3R,4S)-1-acetyl-3-fluoropiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile NA 444000 NA NA NA NA BindingDB
JAK2 3-((2-Cyano-4-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)phenoxy)methyl)oxetane-3-carbonitrile NA 216000 NA NA NA NA BindingDB
JAK2 US10040781, Example 354 NA 309000 NA NA NA NA BindingDB
JAK2 US10040781, Example 363 NA 665000 NA NA NA NA BindingDB
JAK2 US10040781, Example 179 NA 234000 NA NA NA NA BindingDB
JAK2 US10040781, Example 221 NA 488000 NA NA NA NA BindingDB
JAK2 2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile NA 389000 NA NA NA NA BindingDB
JAK2 US10040781, Example 463 NA 272000 NA NA NA NA BindingDB
JAK2 US10040781, Example 230 NA 233000 NA NA NA NA BindingDB
JAK2 US10040781, Example 367 NA 1000000 NA NA NA NA BindingDB
JAK2 US10040781, Example 429 NA 601000 NA NA NA NA BindingDB
JAK2 US10040781, Example 432 NA 140000 NA NA NA NA BindingDB
JAK2 (S)-2-(3-hydroxypyrrolidin-1-yl)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile NA 315000 NA NA NA NA BindingDB
JAK2 US10040781, Example 550 NA 750000 NA NA NA NA BindingDB