| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| JAK2 |
2-((3,3-difluoro-1-(1H-pyrrole-2-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
583000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((1-(2-Hydroxyacetyl)-3-methylpiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
255000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 484 |
NA |
837000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 472 |
NA |
971000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 345 |
NA |
213000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 411 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 373 |
NA |
146000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 168 |
NA |
877000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 359 |
NA |
995000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 570 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 580 |
NA |
165000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 243 |
NA |
130000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-methyl 3-(2-cyano-4-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)phenoxy)pyrrolidine-1-carboxylate |
NA |
660000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 469 |
NA |
197000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((1-ethyl-3-methyl-1H-pyrazol-4-yl)amino)-1,3,5-triazin-2-yl)-2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 470 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((R)-2-oxothiazolidine-4-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
289000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 482 |
NA |
221000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 541 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
N-(2-(4-(2-cyano-4-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)phenoxy)piperidin-1-yl)-2-oxoethyl)formamide |
NA |
408000 |
NA |
NA |
NA |
NA |
BindingDB |