| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| JAK2 |
US10040781, Example 507 |
NA |
432000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((4-(4-(Oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-(1-oxa-7-azaspiro[3.5]nonan-7-yl)benzonitrile |
NA |
301000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((2R,4R)-1-((S)-2-hydroxypropanoyl)-2-methylpiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(S)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydrofuran-3-yl)oxy)benzonitrile |
NA |
281000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(tetrahydro-2H-pyran-4-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
146000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(2-oxoimidazolidine-4-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
163000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((2S,4S)-1-((R)-2-hydroxypropanoyl)-2-methylpiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
491000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 262 |
NA |
156000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 585 |
NA |
294000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(3-methyl-1H-pyrazole-5-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
164000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 341 |
NA |
153000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(3R,4S)-4-(2-cyano-4-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)phenoxy)-3-fluoro-N-hydroxypiperidine-1-carboxamide |
NA |
135000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 415 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((1-(1H-pyrrole-3-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((1,5-dimethyl-1H-pyrazol-4-yl)amino)-1,3,5-triazin-2-yl)-2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(1-hydroxycyclopropanecarbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
341000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 539 |
NA |
519000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-4-((4-(3-cyano-4-((1-(2-hydroxyacetyl)pyrrolidin-3-yl)oxy)phenyl)-1,3,5-triazin-2-yl)amino)benzamide |
NA |
678000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((4S,5R)-5-methyl-2-oxooxazolidine-4-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
811000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((4-morpholinophenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile |
NA |
436000 |
NA |
NA |
NA |
NA |
BindingDB |