| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| JAK2 |
2-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
540000|804000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 263 |
NA |
158000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-1-(3-chloro-1H-pyrazole-5-carbonyl)-3-fluoropiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
237000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 287 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 514 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((S)-4-oxoazetidine-2-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
356000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((1-Methyl-6-oxopiperidin-3-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
849000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 589 |
NA |
855000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 371 |
NA |
989000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 513 |
NA |
517000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-2-((1-(3-hydroxypropanoyl)pyrrolidin-3-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
359000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 80 |
NA |
389000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 380 |
NA |
891000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-1-((S)-2,3-dihydroxypropanoyl)-3-fluoropiperidin-4-yl)oxy)-5-(4-((4-(((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)oxy)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
763000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((1-(1-Hydroxycyclopropanecarbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
918000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 587 |
NA |
235000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
479000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-4-yl)oxy)-3-methyl-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile |
NA |
162000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((1-(tert-butyl)-1H-pyrazol-4-yl)amino)-1,3,5-triazin-2-yl)-2-(((3R,4S)-3-fluoro-1-(3-hydroxypropanoyl)piperidin-4-yl)oxy)benzonitrile |
NA |
223000 |
NA |
NA |
NA |
NA |
BindingDB |