| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((3-methyl-4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
137000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 488 |
NA |
131000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
3-fluoro-2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
648000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((3-(2-hydroxypropan-2-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
767000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(S)-3-((1-(2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
371000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 132 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 468 |
NA |
486000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 391 |
NA |
122000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((4-(4-(Oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-(pyrrolidin-1-yl)benzonitrile |
NA |
336000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((1-(2-Hydroxyacetyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
603000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((4-(1-methylpiperidin-4-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile |
NA |
575000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((R)-3-hydroxy-2-methylpropanoyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
676000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 116 |
NA |
146000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-4-yl)oxy)-5-(4-((3-fluoro-4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
199000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 128 |
NA |
632000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((1-(2-Cyanoacetyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
444000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy)-5-(4-((3-fluoro-4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
527000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((1-(2-Hydroxyacetyl)azetidin-3-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 244 |
NA |
191000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 489 |
NA |
183000 |
NA |
NA |
NA |
NA |
BindingDB |