| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| JAK2 |
2-(1,4-Dioxaspiro[4.5]decan-8-yloxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((1-(tert-butyl)-1H-pyrazol-4-yl)amino)-1,3,5-triazin-2-yl)-2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)benzonitrile |
NA |
228000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((3-fluoro-4-(4-formylpiperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-(((3R,4S)-3-fluorotetrahydro-2H-pyran-4-yl)oxy)benzonitrile |
NA |
401000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 535 |
NA |
904000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((3-(difluoromethoxy)-4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)benzonitrile |
NA |
119000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-1-(3,5-dimethyl-1H-pyrazole-4-carbonyl)-3-fluoropiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
212000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 409 |
NA |
327000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 466 |
NA |
422000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 102 |
NA |
380000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 226 |
NA |
311000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((1-ethyl-3-methyl-1H-pyrazol-4-yl)amino)-1,3,5-triazin-2-yl)-2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-4-yl)oxy)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 251 |
NA |
369000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(2-methoxyacetyl)piperidin-4-yl)oxy)-5-(4-((4-(1-formylpiperidin-4-yl)-3-methylphenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
482000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((4-(4-(Oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-(1-oxa-6-azaspiro[3.3]heptan-6-yl)benzonitrile |
NA |
354000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((4-Methoxycyclohexyl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
402000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
rac-2-(((1S,2R)-2-fluorocyclohexyl)oxy)-5-(4-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
154000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((3-methoxy-4-(methylsulfonyl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 485 |
NA |
576000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(4-methyl-1H-imidazole-2-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
323000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 318 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |