DrugSearch

Result

This table shows the results of the FOX gene Drug analysis in Cancer, including FOX gene name (Gene_Symbol), FOX gene ID (Ensembl_Gene_ID), Drug Name (DrugName), Drug target genes (Drug_Target), Drug target genes ID (Target_ensembol), Correlation of target genes and drugs (Target_cor), P-value of target genes and drugs (Target_Pvalue), Correlation of FOX genes and drugs (FOX_cor), P-value of FOX genes and drugs (FOX_Pvalue)

 Gene_Symbol  Ensembl_Gene_ID  DrugName  Drug_Target  Target_ensembol  Pathway  Target_cor  Target_Pvalue  FOX_cor  FOX_Pvalue
 FOXA1  ENSG00000129514  AZD4547  FGFR1  ENSG00000077782  RTK signaling  -0.24  5.30E-15  0.23  3.00E-12
 FOXA1  ENSG00000129514  AZD4547  FGFR3  ENSG00000068078  RTK signaling  0.28  9.26E-20  0.23  3.00E-12
 FOXA1  ENSG00000129514  CHIR-99021  GSK3B  ENSG00000082701  WNT signaling  0.2  8.46E-11  0.27  4.27E-30
 FOXA1  ENSG00000129514  Foretinib  FGFR1  ENSG00000077782  RTK signaling  -0.24  5.30E-15  0.25  4.51E-14
 FOXA1  ENSG00000129514  Masitinib  PDGFRB  ENSG00000113721  RTK signaling  -0.3  5.77E-22  0.21  5.58E-10
 FOXA1  ENSG00000129514  MG-132  CAPN1  ENSG00000014216  Protein stability and degradation  0.25  2.06E-16  0.21  3.14E-05
 FOXA1  ENSG00000129514  Ponatinib  FGFR1  ENSG00000077782  kinases  -0.24  5.30E-15  0.25  3.82E-14
 FOXA1  ENSG00000129514  Ponatinib  FGFR1  ENSG00000077782  Other  -0.24  5.30E-15  0.25  3.82E-14
 FOXA1  ENSG00000129514  Ponatinib  SRC  ENSG00000197122  Other  0.24  7.44E-15  0.25  3.82E-14
 FOXA1  ENSG00000129514  Ponatinib  SRC  ENSG00000197122  kinases  0.24  7.44E-15  0.25  3.82E-14
 FOXA1  ENSG00000129514  QL-XI-92  DDR1  ENSG00000204580  Cytoskeleton  0.48  1.08E-58  0.23  1.74E-12
 FOXA1  ENSG00000129514  SB216763  GSK3B  ENSG00000082701  WNT signaling  0.2  8.46E-11  0.22  1.28E-10
 FOXC1  ENSG00000054598  ACY-1215  HDAC6  ENSG00000094631  Chromatin histone acetylation  -0.23  2.68E-13  0.3  6.26E-20
 FOXC1  ENSG00000054598  Amuvatinib  FLT3  ENSG00000122025  RTK signaling  -0.21  8.90E-12  0.26  1.57E-15
 FOXC1  ENSG00000054598  BX-912  PDK1  ENSG00000152256  Metabolism  -0.24  2.87E-15  0.29  4.67E-19
 FOXC1  ENSG00000054598  CAY10603  HDAC6  ENSG00000094631  Chromatin histone acetylation  -0.23  2.68E-13  0.28  5.73E-17
 FOXC1  ENSG00000054598  Cetuximab  EGFR  ENSG00000146648  EGFR signaling  0.42  7.38E-44  -0.22  1.45E-10
 FOXC1  ENSG00000054598  CP466722  ATM  ENSG00000149311  Genome integrity  -0.24  3.08E-15  0.23  1.75E-12
 FOXC1  ENSG00000054598  CUDC-101  EGFR  ENSG00000146648  Other  0.42  7.38E-44  0.22  3.15E-11
 FOXC1  ENSG00000054598  Dasatinib  SRC  ENSG00000197122  Other  0.24  5.98E-15  -0.22  1.26E-05
 FOXC1  ENSG00000054598  Dasatinib  SRC  ENSG00000197122  kinases  0.24  5.98E-15  -0.22  1.26E-05
 FOXC1  ENSG00000054598  Dasatinib  SRC  ENSG00000197122  RTK signaling  0.24  5.98E-15  -0.22  1.26E-05
 FOXC1  ENSG00000054598  GSK429286A  ROCK1  ENSG00000067900  Cytoskeleton  -0.27  1.87E-18  0.26  4.17E-15
 FOXC1  ENSG00000054598  JW-7-24-1  LCK  ENSG00000182866  Other  -0.28  2.78E-19  0.28  2.63E-17
 FOXC1  ENSG00000054598  JW-7-24-1  LCK  ENSG00000182866  kinases  -0.28  2.78E-19  0.28  2.63E-17
 FOXC1  ENSG00000054598  KIN001-244  PDK1  ENSG00000152256  Metabolism  -0.24  2.87E-15  0.28  8.51E-18
 FOXC1  ENSG00000054598  Navitoclax  BCL2  ENSG00000171791  Apoptosis regulation  -0.4  2.08E-41  0.3  2.63E-20
 FOXC1  ENSG00000054598  NG-25  MAP4K2  ENSG00000168067  Other  -0.21  9.17E-12  0.28  3.48E-17
 FOXC1  ENSG00000054598  NG-25  MAP4K2  ENSG00000168067  kinases  -0.21  9.17E-12  0.28  3.48E-17
 FOXC1  ENSG00000054598  Olaparib  PARP1  ENSG00000143799  Genome integrity  -0.36  2.75E-32  0.21  2.65E-10
 FOXC1  ENSG00000054598  Pemetrexed  TYMS  ENSG00000176890  DNA replication  -0.22  3.52E-12  0.26  2.90E-15
 FOXC1  ENSG00000054598  PIK-93  PIK3CG  ENSG00000105851  PI3K/MTOR signaling  -0.37  4.58E-35  0.32  1.32E-22
 FOXC1  ENSG00000054598  QL-X-138  BTK  ENSG00000010671  Other  -0.36  1.11E-31  0.24  2.09E-13
 FOXC1  ENSG00000054598  QL-X-138  BTK  ENSG00000010671  kinases  -0.36  1.11E-31  0.24  2.09E-13
 FOXC1  ENSG00000054598  QL-XI-92  DDR1  ENSG00000204580  Cytoskeleton  0.41  7.10E-42  0.3  1.15E-20
 FOXC1  ENSG00000054598  Quizartinib  FLT3  ENSG00000122025  RTK signaling  -0.21  8.90E-12  0.31  5.94E-21
 FOXC1  ENSG00000054598  Selisistat  SIRT1  ENSG00000096717  Chromatin histone acetylation  -0.2  5.24E-11  0.22  2.16E-11
 FOXC1  ENSG00000054598  SGC0946  DOT1L  ENSG00000104885  Chromatin histone methylation  -0.35  6.81E-30  0.21  4.37E-10
 FOXC1  ENSG00000054598  SU11274  MET  ENSG00000105976  RTK signaling  0.39  3.44E-38  0.25  2.09E-14
 FOXC1  ENSG00000054598  Tubastatin A  HDAC6  ENSG00000094631  Chromatin histone acetylation  -0.23  2.68E-13  0.33  2.65E-24
 FOXC1  ENSG00000054598  WZ3105  SRC  ENSG00000197122  Other  0.24  5.98E-15  0.25  1.60E-14
 FOXC1  ENSG00000054598  WZ3105  FLT3  ENSG00000122025  Other  -0.21  8.90E-12  0.25  1.60E-14
 FOXC1  ENSG00000054598  XMD13-2  RIPK1  ENSG00000137275  Apoptosis regulation  0.2  4.06E-11  0.29  6.85E-19
 FOXC1  ENSG00000054598  YM201636  PIKFYVE  ENSG00000115020  PI3K/MTOR signaling  -0.33  1.48E-26  0.27  1.90E-16
 FOXD4  ENSG00000170122  PIK-93  PIK3CG  ENSG00000105851  PI3K/MTOR signaling  0.22  4.39E-13  -0.21  1.15E-10
 FOXE1  ENSG00000178919  Afatinib  EGFR  ENSG00000146648  EGFR signaling  0.39  6.04E-39  -0.22  1.51E-21
 FOXE1  ENSG00000178919  Cetuximab  EGFR  ENSG00000146648  EGFR signaling  0.39  6.04E-39  -0.22  1.37E-10
 FOXE1  ENSG00000178919  Erlotinib  EGFR  ENSG00000146648  EGFR signaling  0.39  6.04E-39  -0.26  2.93E-07
 FOXE1  ENSG00000178919  Gefitinib  EGFR  ENSG00000146648  EGFR signaling  0.39  6.04E-39  -0.26  4.54E-16
 FOXE1  ENSG00000178919  Lapatinib  EGFR  ENSG00000146648  EGFR signaling  0.39  6.04E-39  -0.26  3.33E-07
 FOXE1  ENSG00000178919  Lapatinib  EGFR  ENSG00000146648  RTK signaling  0.39  6.04E-39  -0.26  3.33E-07
 FOXF2  ENSG00000137273  ACY-1215  HDAC6  ENSG00000094631  Chromatin histone acetylation  -0.2  9.67E-11  0.24  1.20E-13
 FOXF2  ENSG00000137273  CAY10603  HDAC6  ENSG00000094631  Chromatin histone acetylation  -0.2  9.67E-11  0.22  8.73E-11
 FOXF2  ENSG00000137273  Tubastatin A  HDAC6  ENSG00000094631  Chromatin histone acetylation  -0.2  9.67E-11  0.22  1.27E-11
 FOXJ3  ENSG00000198815  A-770041  FYN  ENSG00000010810  Other  0.29  1.70E-20  0.22  9.83E-06
 FOXJ3  ENSG00000198815  A-770041  FYN  ENSG00000010810  kinases  0.29  1.70E-20  0.22  9.83E-06
 FOXJ3  ENSG00000198815  ACY-1215  HDAC6  ENSG00000094631  Chromatin histone acetylation  0.2  9.04E-11  -0.22  3.70E-11
 FOXJ3  ENSG00000198815  Dasatinib  KIT  ENSG00000157404  Other  0.26  3.16E-17  0.24  1.39E-06
 FOXJ3  ENSG00000198815  Dasatinib  KIT  ENSG00000157404  kinases  0.26  3.16E-17  0.24  1.39E-06
 FOXJ3  ENSG00000198815  Dasatinib  KIT  ENSG00000157404  RTK signaling  0.26  3.16E-17  0.24  1.39E-06
 FOXJ3  ENSG00000198815  Tubastatin A  HDAC6  ENSG00000094631  Chromatin histone acetylation  0.2  9.04E-11  -0.22  6.92E-11
 FOXK2  ENSG00000141568  ACY-1215  HDAC6  ENSG00000094631  Chromatin histone acetylation  0.21  1.36E-11  -0.23  4.96E-12
 FOXN2  ENSG00000170802  Lapatinib  EGFR  ENSG00000146648  RTK signaling  -0.29  4.75E-21  0.26  3.05E-07
 FOXN2  ENSG00000170802  Lapatinib  EGFR  ENSG00000146648  EGFR signaling  -0.29  4.75E-21  0.26  3.05E-07
 FOXN3  ENSG00000053254  GSK429286A  ROCK1  ENSG00000067900  Cytoskeleton  0.29  4.16E-21  -0.24  1.06E-12
 FOXN3  ENSG00000053254  I-BET-762  BRD3  ENSG00000169925  Chromatin other  0.24  8.08E-15  -0.27  1.59E-16
 FOXN3  ENSG00000053254  I-BET-762  BRD4  ENSG00000141867  Chromatin other  0.25  1.94E-16  -0.27  1.59E-16
 FOXN3  ENSG00000053254  JW-7-24-1  LCK  ENSG00000182866  Other  0.24  1.34E-14  -0.22  2.21E-11
 FOXN3  ENSG00000053254  JW-7-24-1  LCK  ENSG00000182866  kinases  0.24  1.34E-14  -0.22  2.21E-11
 FOXN3  ENSG00000053254  Linifanib  FLT3  ENSG00000122025  RTK signaling  0.21  1.48E-11  -0.21  5.34E-10
 FOXN3  ENSG00000053254  Navitoclax  BCL2  ENSG00000171791  Apoptosis regulation  0.4  1.55E-39  -0.29  8.41E-20
 FOXN3  ENSG00000053254  PI-103  CLK4  ENSG00000113240  Other  0.24  2.32E-15  -0.21  3.00E-10
 FOXN3  ENSG00000053254  PI-103  CLK4  ENSG00000113240  kinases  0.24  2.32E-15  -0.21  3.00E-10
 FOXN3  ENSG00000053254  QL-XI-92  DDR1  ENSG00000204580  Cytoskeleton  -0.38  5.92E-36  -0.25  1.77E-14
 FOXN3  ENSG00000053254  QL-XII-61  BTK  ENSG00000010671  Other  0.32  5.17E-26  -0.23  6.68E-07
 FOXN3  ENSG00000053254  QL-XII-61  BTK  ENSG00000010671  kinases  0.32  5.17E-26  -0.23  6.68E-07
 FOXN3  ENSG00000053254  Quizartinib  FLT3  ENSG00000122025  RTK signaling  0.21  1.48E-11  -0.28  2.67E-17
 FOXN3  ENSG00000053254  Tubastatin A  HDAC6  ENSG00000094631  Chromatin histone acetylation  0.24  8.53E-15  -0.25  1.56E-14
 FOXN4  ENSG00000139445  A-770041  FYN  ENSG00000010810  Other  0.26  1.85E-17  0.2  6.63E-05
 FOXN4  ENSG00000139445  A-770041  FYN  ENSG00000010810  kinases  0.26  1.85E-17  0.2  6.63E-05
 FOXN4  ENSG00000139445  ACY-1215  HDAC6  ENSG00000094631  Chromatin histone acetylation  0.26  9.32E-18  -0.22  3.38E-11
 FOXN4  ENSG00000139445  Dasatinib  KIT  ENSG00000157404  Other  0.26  8.23E-18  0.25  9.63E-07
 FOXN4  ENSG00000139445  Dasatinib  KIT  ENSG00000157404  kinases  0.26  8.23E-18  0.25  9.63E-07
 FOXN4  ENSG00000139445  Dasatinib  KIT  ENSG00000157404  RTK signaling  0.26  8.23E-18  0.25  9.63E-07
 FOXQ1  ENSG00000164379  ACY-1215  HDAC6  ENSG00000094631  Chromatin histone acetylation  -0.23  2.17E-13  0.27  2.79E-16
 FOXQ1  ENSG00000164379  CAY10603  HDAC6  ENSG00000094631  Chromatin histone acetylation  -0.23  2.17E-13  0.22  2.51E-11
 FOXQ1  ENSG00000164379  Cetuximab  EGFR  ENSG00000146648  EGFR signaling  0.42  1.11E-45  -0.21  1.14E-09
 FOXQ1  ENSG00000164379  Erlotinib  EGFR  ENSG00000146648  EGFR signaling  0.42  1.11E-45  -0.22  1.01E-05
 FOXQ1  ENSG00000164379  GSK269962A  ROCK1  ENSG00000067900  Cytoskeleton  -0.21  5.27E-12  0.23  1.04E-16
 FOXQ1  ENSG00000164379  KIN001-244  PDK1  ENSG00000152256  Metabolism  -0.27  6.27E-18  0.22  3.24E-11
 FOXQ1  ENSG00000164379  Lapatinib  ERBB2  ENSG00000141736  EGFR signaling  0.24  3.57E-15  -0.28  2.63E-08
 FOXQ1  ENSG00000164379  Lapatinib  ERBB2  ENSG00000141736  RTK signaling  0.24  3.57E-15  -0.28  2.63E-08
 FOXQ1  ENSG00000164379  Lapatinib  EGFR  ENSG00000146648  RTK signaling  0.42  1.11E-45  -0.28  2.63E-08
 FOXQ1  ENSG00000164379  Lapatinib  EGFR  ENSG00000146648  EGFR signaling  0.42  1.11E-45  -0.28  2.63E-08
 FOXQ1  ENSG00000164379  NSC-207895  MDM4  ENSG00000198625  p53 pathway  -0.33  2.65E-27  0.23  1.82E-12
 FOXQ1  ENSG00000164379  Olaparib  PARP1  ENSG00000143799  Genome integrity  -0.4  6.81E-41  0.21  4.91E-11
 FOXQ1  ENSG00000164379  QL-X-138  BTK  ENSG00000010671  Other  -0.23  5.49E-14  0.22  7.79E-11
 FOXQ1  ENSG00000164379  QL-X-138  BTK  ENSG00000010671  kinases  -0.23  5.49E-14  0.22  7.79E-11
 FOXQ1  ENSG00000164379  QL-XI-92  DDR1  ENSG00000204580  Cytoskeleton  0.49  5.16E-63  0.27  6.73E-16
 FOXQ1  ENSG00000164379  SU11274  MET  ENSG00000105976  RTK signaling  0.4  2.11E-41  0.22  1.23E-11
 FOXQ1  ENSG00000164379  Tubastatin A  HDAC6  ENSG00000094631  Chromatin histone acetylation  -0.23  2.17E-13  0.27  8.41E-17
 FOXQ1  ENSG00000164379  TW 37  BCL2  ENSG00000171791  Apoptosis regulation  -0.3  1.63E-22  0.21  8.37E-11
 FOXQ1  ENSG00000164379  YM201636  PIKFYVE  ENSG00000115020  PI3K/MTOR signaling  -0.32  8.08E-26  0.21  4.82E-10