| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| ACHE |
ethyl 2-[[2-[4-[(E)-hydroxyiminomethyl]pyridin-1-ium-1-yl]acetyl]amino]-1,3-thiazole-4-carboxylate;chloride |
NA |
2490000 |
NA |
NA |
NA |
NA |
TTD |
| ACHE |
4-(4-fluorophenyl)-1-[(4-methoxy-3-phenylmethoxyphenyl)methyl]-3,6-dihydro-2H-pyridine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| ACHE |
2-[4-(Benzyloxy)benzyl]-1,2,3,4-tetrahydroisoquinoline |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| ACHE |
4-chloro-2-[[4-[(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)methyl]piperidin-1-yl]methyl]-6-[(E)-hydroxyiminomethyl]phenol |
NA |
940800 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
2-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-6-[(E)-hydroxyiminomethyl]phenol |
NA |
1265000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
6-[2-[(Z)-hydroxyiminomethyl]-3-methylimidazol-3-ium-1-yl]-N-[(4-methoxyphenyl)methyl]-N-[2-oxo-2-(propan-2-ylamino)ethyl]hexanamide;iodide |
NA |
NA|1000000 |
115900|NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
2-[(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-6-[(E)-hydroxyiminomethyl]-4-methylphenol |
NA |
1124000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
N-[2-(benzylamino)-2-oxoethyl]-6-[2-[(Z)-hydroxyiminomethyl]-3-methylimidazol-3-ium-1-yl]-N-[(4-methoxyphenyl)methyl]hexanamide;iodide |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| ACHE |
2-[[4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]piperidin-1-yl]methyl]-6-[(E)-hydroxyiminomethyl]phenol |
NA |
802400 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
2-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-4-fluoro-6-[(E)-hydroxyiminomethyl]phenol |
NA |
692500 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
2-[[4-[(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)methyl]piperidin-1-yl]methyl]-4-fluoro-6-[(E)-hydroxyiminomethyl]phenol |
NA |
684500 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
2-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-6-[(E)-hydroxyiminomethyl]-4-methylphenol |
NA |
1058000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
2-[[4-[(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)methyl]piperidin-1-yl]methyl]-6-[(E)-hydroxyiminomethyl]-4-methoxyphenol |
NA |
543400 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
N-[2-(benzylamino)-2-oxoethyl]-6-[2-[(E)-hydroxyiminomethyl]imidazol-1-yl]-N-[(4-methoxyphenyl)methyl]hexanamide |
NA |
NA|180000 |
140300|155000|274000|NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
2-[[4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]piperidin-1-yl]methyl]-4-fluoro-6-[(E)-hydroxyiminomethyl]phenol |
NA |
NA|658100 |
268000|NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
4-[[4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]piperidin-1-yl]methyl]-2-[(E)-hydroxyiminomethyl]phenol |
NA |
393300 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
1-(3-Chlorophenyl)-3-(2-piperidin-1-ylethyl)thiourea |
NA |
190000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
N-butyl-6-[2-[(E)-hydroxyiminomethyl]imidazol-1-yl]-N-[2-oxo-2-(propan-2-ylamino)ethyl]hexanamide |
NA |
NA|1000000 |
1144000|1961000|NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
N-[2-(benzylamino)-2-oxoethyl]-6-[2-[(E)-hydroxyiminomethyl]imidazol-1-yl]-N-(2-methoxyethyl)hexanamide |
NA |
NA|1000000 |
782000|1655000|NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
2-[(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-6-[(E)-hydroxyiminomethyl]phenol |
NA |
907800 |
NA |
NA |
NA |
NA |
BindingDB|TTD |