| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| ACHE |
2-[[4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]piperidin-1-yl]methyl]-6-[(E)-hydroxyiminomethyl]-4-methylphenol |
NA |
417500 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
2-[[4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]piperidin-1-yl]methyl]-6-[(E)-hydroxyiminomethyl]-4-methoxyphenol |
NA |
NA|847900 |
512000|NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
6-[2-[(E)-hydroxyiminomethyl]imidazol-1-yl]-N-[(4-methoxyphenyl)methyl]-N-[2-oxo-2-(propan-2-ylamino)ethyl]hexanamide |
NA |
NA|1000000 |
527000|NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
2-[[4-[(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)methyl]piperidin-1-yl]methyl]-6-[(E)-hydroxyiminomethyl]phenol |
NA |
740400 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-2-[(E)-hydroxyiminomethyl]phenol |
NA |
559300 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
4-bromo-2-[[4-[(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)methyl]piperidin-1-yl]methyl]-6-[(E)-hydroxyiminomethyl]phenol |
NA |
977400 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
4-chloro-2-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-6-[(E)-hydroxyiminomethyl]phenol |
NA |
1567000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
2-[(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-6-[(E)-hydroxyiminomethyl]-4-methoxyphenol |
NA |
911300 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
1-(3-Chlorophenyl)-3-[2-(4-methylpiperidin-1-yl)ethyl]thiourea |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| ACHE |
(E)-3-[4-[4-(dimethylamino)butoxy]-3-methoxyphenyl]-N-phenylprop-2-enamide |
NA |
100500 |
NA |
NA |
NA |
NA |
TTD |
| ACHE |
N-[2-(benzylamino)-2-oxoethyl]-N-butyl-6-[2-[(Z)-hydroxyiminomethyl]-3-methylimidazol-3-ium-1-yl]hexanamide;iodide |
NA |
NA |
122000|352000 |
NA |
NA |
NA |
BindingDB |
| ACHE |
2-[(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-4-fluoro-6-[(E)-hydroxyiminomethyl]phenol |
NA |
754700 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
4-bromo-2-[[4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]piperidin-1-yl]methyl]-6-[(E)-hydroxyiminomethyl]phenol |
NA |
NA|568000 |
204000|NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
1-(4-Chloro-3-methoxyphenyl)-3-(2-morpholin-4-ylethyl)thiourea |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| ACHE |
2-[[4-[(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)methyl]piperidin-1-yl]methyl]-6-[(E)-hydroxyiminomethyl]-4-methylphenol |
NA |
524700 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
[Ethoxy(ethylsulfanyl)phosphoryl]benzene |
NA |
150000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
N-butyl-6-[2-[(Z)-hydroxyiminomethyl]-3-methylimidazol-3-ium-1-yl]-N-[2-oxo-2-(propan-2-ylamino)ethyl]hexanamide;iodide |
NA |
NA|1000000 |
121000|167000|213000|NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
N-[2-(benzylamino)-2-oxoethyl]-N-butyl-6-[2-[(E)-hydroxyiminomethyl]imidazol-1-yl]hexanamide |
NA |
NA|1000000 |
228900|815800|1199500|NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
4-chloro-2-[(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-6-[(E)-hydroxyiminomethyl]phenol |
NA |
1207000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| ACHE |
4-bromo-2-[(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-6-[(E)-hydroxyiminomethyl]phenol |
NA |
895800 |
NA |
NA |
NA |
NA |
BindingDB|TTD |