| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TOP2A |
(-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, hemihydrate |
NA |
NA |
NA |
280000 |
NA |
NA |
PubChem |
| TOP2A |
Bakuchicin |
NA |
404000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
2-fluoro-N-((4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
6-(cyclopentylsulfanylmethyl)-2-N-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
N-(2-bromophenyl)-4,6-dichloro-1,3,5-triazin-2-amine |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
Etoposide |
NA |
110000|120000 |
NA |
NA |
NA |
NA |
BindingDB|PubChem |
| TOP2A |
9-Amino-5,6-difluoro-3-oxo-3H-pyrido[3,2,1-kl]phenoxazine-2-carboxylic acid |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
{4-Amino-6-[(4-fluorophenyl)amino]-1,3,5-triazin-2-yl}methyl cyclohexyl(methyl)carbamodithioate |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
2-[(2-methylpyridin-4-yl)methylamino]-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carboxamide |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
2-[(2-Methylpyridin-4-yl)methylamino]pyridine-3-carboxamide |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
6-Methyl-2-{[(2-methyl-4-pyridinyl)methyl]amino}nicotinamide |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
2-[(3,4-Dimethoxyphenyl)methylamino]pyridine-3-carboxamide |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
(2S)-2-[(4,6-diamino-1,3,5-triazin-2-yl)sulfanyl]-1-morpholin-4-ylpropan-1-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
Methyl 2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoate |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
N-[(4-phenyl-5-sulfanylidene-1H-1,2,4-triazol-3-yl)methyl]-2-(trifluoromethyl)benzamide |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
N-{[4-(3,4-Dichlorophenyl)-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-3-YL]methyl}-3-methoxybenzamide |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
Ginsenoside B2 |
NA |
250000 |
NA |
NA |
NA |
NA |
PubChem|TTD |
| TOP2A |
2-[[1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxoquinolin-3-yl]methyl]benzoic acid |
NA |
NA |
NA |
200000 |
NA |
NA |
BindingDB|TTD |
| TOP2A |
3-(Cyclohexylmethyl)-1-cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoroquinolin-4-one |
NA |
NA |
NA |
230000 |
NA |
NA |
TTD |
| TOP2A |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-3-(naphthalen-1-ylmethyl)quinolin-4-one |
NA |
NA |
NA |
210000 |
NA |
NA |
TTD |