| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TOP2A |
3-[[2-[(4-chlorophenyl)methylsulfanyl]-6-oxo-1H-1,3,5-triazin-4-yl]sulfanylmethyl]benzoic acid |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
3-[[4-[(3-chlorophenyl)methylsulfanyl]-6-oxo-1H-1,3,5-triazin-2-yl]sulfanylmethyl]benzamide |
NA |
451400 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
[(2R,4aR,6R,7R,8R,8aS)-6-[[(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-5-yl]oxy]-7-[[2-[(5-fluoro-1,3-benzothiazol-2-yl)sulfanyl]acetyl]amino]-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-yl] 2-[(5-fluoro-1,3-benzothiazol-2-yl)sulfanyl]acetate |
NA |
116500 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TOP2A |
4-[(4-chlorophenyl)methylsulfanyl]-6-[[4-(hydroxymethyl)phenyl]methylsulfanyl]-1H-1,3,5-triazin-2-one |
NA |
154900 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
6-[(2-fluorophenyl)methylsulfanyl]-4-[(2,4,5-trifluorophenyl)methylsulfanyl]-1H-1,3,5-triazin-2-one |
NA |
164100 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
(4'R,6'S,7'S)-17'-fluoro-4',6'-dimethyl-13'-(6-oxo-5-oxa-7-azaspiro[3.4]octan-7-yl)spiro[1,3-diazinane-5,8'-5,15-dioxa-2,14-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(17),10,12(16),13-tetraene]-2,4,6-trione |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
3-[[2-[(2-fluorophenyl)methylsulfanyl]-6-oxo-1H-1,3,5-triazin-4-yl]sulfanylmethyl]benzamide |
NA |
716000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
[(2R,4aR,6R,7R,8R,8aS)-6-[[(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-5-yl]oxy]-7-[[2-[(5-fluoro-1,3-benzoxazol-2-yl)sulfanyl]acetyl]amino]-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-yl] 2-[(5-fluoro-1,3-benzoxazol-2-yl)sulfanyl]acetate |
NA |
124200 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TOP2A |
6-[(4-chlorophenyl)methylsulfanyl]-4-[(3-hydroxyphenyl)methylsulfanyl]-1H-1,3,5-triazin-2-one |
NA |
129100 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
6-[(2,6-difluorophenyl)methylsulfanyl]-4-[(2-fluorophenyl)methylsulfanyl]-1H-1,3,5-triazin-2-one |
NA |
170800 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
3-[[2-[(4-chlorophenyl)methylsulfanyl]-6-oxo-1H-1,3,5-triazin-4-yl]sulfanylmethyl]benzamide |
NA |
293400 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
2-[4-[[4-[(3-chlorophenyl)methylsulfanyl]-6-oxo-1H-1,3,5-triazin-2-yl]sulfanylmethyl]phenyl]propanoic acid |
NA |
145100 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
(4'R,6'S,7'S)-17'-fluoro-4',6'-dimethyl-13'-(5-oxo-4-oxa-6-azaspiro[2.4]heptan-6-yl)spiro[1,3-diazinane-5,8'-5,15-dioxa-2,14-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(17),10,12(16),13-tetraene]-2,4,6-trione |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
4-[(3,5-dimethoxyphenyl)methylsulfanyl]-6-[(2-fluorophenyl)methylsulfanyl]-1H-1,3,5-triazin-2-one |
NA |
422100 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
4-hydroxy-N-[(4-hydroxy-3,5-dimethoxyphenyl)methyl]-6-oxo-1,3-diphenyl-2-sulfanylidenepyrimidine-5-carboxamide |
NA |
107800 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
2-[4-[[4-[(4-chlorophenyl)methylsulfanyl]-6-oxo-1H-1,3,5-triazin-2-yl]sulfanylmethyl]phenyl]propanoic acid |
NA |
161400 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
6-[(2-fluorophenyl)methylsulfanyl]-4-[(3-hydroxyphenyl)methylsulfanyl]-1H-1,3,5-triazin-2-one |
NA |
128400 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
3-[[2-[(2-fluorophenyl)methylsulfanyl]-6-oxo-1H-1,3,5-triazin-4-yl]sulfanylmethyl]benzoic acid |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
3-[[4-[(3-chlorophenyl)methylsulfanyl]-6-oxo-1H-1,3,5-triazin-2-yl]sulfanylmethyl]benzoic acid |
NA |
388100 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
4-(2,1,3-benzoxadiazol-5-ylmethylsulfanyl)-6-[(2-fluorophenyl)methylsulfanyl]-1H-1,3,5-triazin-2-one |
NA |
268900 |
NA |
NA |
NA |
NA |
TTD |