| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TOP2A |
{4-Amino-6-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}methyl piperidine-1-carbodithioate |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
4-Chloro-10,11-difluoro-5-nitro-14-oxo-8-oxa-1-azatetracyclo[7.7.1.02,7.013,17]heptadeca-2,4,6,9(17),10,12,15-heptaene-15-carboxylic acid |
NA |
125000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-fluoro-8-methoxy-1-(naphthalen-2-ylmethyl)-4-oxoquinoline-3-carboxylic acid |
NA |
164600 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-fluoro-8-methoxy-4-oxo-1-[(4-phenylphenyl)methyl]quinoline-3-carboxylic acid |
NA |
127600 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
2-((3-(1H-imidazol-1-yl)propyl)amino)-6-methylpyrimidin-4-ol |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
4-amino-2-[(2S)-1-morpholin-4-yl-1-oxopropan-2-yl]sulfanyl-1H-pyrimidin-6-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
4-methyl-2-[(2Z)-2-(pyridin-3-ylmethylidene)hydrazinyl]-1H-pyrimidin-6-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
4-methyl-2-[(2Z)-2-(pyridin-4-ylmethylidene)hydrazinyl]-1H-pyrimidin-6-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
4-hydroxy-N-(4-hydroxyphenyl)-6-oxo-1,3-diphenyl-2-sulfanylidenepyrimidine-5-carboxamide |
NA |
150000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
(5S)-4-[2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl]-5-(hydroxymethyl)oxolan-2-one |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
(4S,5S)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-4-[(3,4-dimethoxyphenyl)methyl]oxolan-2-one |
NA |
137000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
4-hydroxy-N-(3-hydroxyphenyl)-6-oxo-1,3-diphenyl-2-sulfanylidenepyrimidine-5-carboxamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
4-hydroxy-N-(4-hydroxy-3,5-dimethoxyphenyl)-6-oxo-1,3-diphenyl-2-sulfanylidenepyrimidine-5-carboxamide |
NA |
120000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
(2~{R})-2-[[5-(2-chlorophenyl)-1,2-benzoxazol-3-yl]oxy]-2-phenyl-ethanamine |
NA |
210000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
4-[3-(4-phenylmethoxyphenyl)-1H-pyrazol-5-yl]piperidine |
NA |
599000 |
NA |
NA |
NA |
NA |
BindingDB |
| TOP2A |
{4-Amino-6-[(4-fluorophenyl)amino]-1,3,5-triazin-2-yl}methyl morpholine-4-carbodithioate |
NA |
139000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
1-Ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid |
NA |
NA |
NA |
570000 |
NA |
NA |
TTD |
| TOP2A |
24-Hydroxy-beta-amyrin |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
3-O-Beta-D-Glucopyranosyl Quinovic Acid |
NA |
250000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
(1S,2R,4aS,6aR,6bR,8aR,10S,12aR,12bR,14bS)-1,2,6b,9,9,12a-hexamethyl-10-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-4a-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)carbonyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-6a-carboxylic acid |
NA |
250000 |
NA |
NA |
NA |
NA |
TTD |