| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TOP2A |
CID 10068583 |
NA |
NA |
NA |
260000 |
NA |
NA |
TTD |
| TOP2A |
1-[(2R,4S,5S)-4-[(3,4-dihydroxyphenyl)methyl]-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione |
NA |
176000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
1-[(2R,4S,5S)-4-[(3,4-dimethoxyphenyl)methyl]-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
N2-(2-(diethylamino)ethyl)-N9-phenylthiazolo[5,4-b]quinoline-2,9-diamine |
NA |
168900 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
N-[[14-[2-(diethylamino)ethyl]-4-methoxy-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-10-yl]methyl]formamide |
NA |
NA |
NA |
240000 |
NA |
NA |
TTD |
| TOP2A |
N-[[1-[2-(diethylamino)ethylamino]-9-oxothioxanthen-4-yl]methyl]formamide |
NA |
NA |
NA |
510000 |
NA |
NA |
BindingDB|TTD |
| TOP2A |
(2S)-6-[(3R)-3-(2-aminopropan-2-yl)pyrrolidin-1-yl]-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13),11-tetraene-11-carboxylic acid |
NA |
403000 |
NA |
NA |
NA |
NA |
BindingDB |
| TOP2A |
(2S)-6-[(3R)-3-[(1S)-1-aminoethyl]pyrrolidin-1-yl]-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13),11-tetraene-11-carboxylic acid |
NA |
106000|142000 |
NA |
NA |
NA |
NA |
BindingDB |
| TOP2A |
methyl N-[[14-[2-(diethylamino)ethyl]-4-methoxy-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-10-yl]methyl]carbamate |
NA |
NA |
NA |
220000 |
NA |
NA |
TTD |
| TOP2A |
methyl N-[[14-[2-(diethylamino)ethyl]-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9,11,13(16)-heptaen-10-yl]methyl]carbamate |
NA |
NA |
NA |
240000 |
NA |
NA |
TTD |
| TOP2A |
(2-(Diethylamino)ethyl]-2H-[1]-benzothiopyrano[4,3,2-cd]indazole-5-methanamine |
NA |
NA |
NA |
250000 |
NA |
NA |
TTD |
| TOP2A |
N-[[14-[2-(diethylamino)ethyl]-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9,11,13(16)-heptaen-10-yl]methyl]formamide |
NA |
NA |
NA |
260000 |
NA |
NA |
TTD |
| TOP2A |
N-[[1-[2-(diethylamino)ethylamino]-7-methoxy-9-oxothioxanthen-4-yl]methyl]methanesulfonamide |
NA |
NA |
NA |
210000 |
NA |
NA |
TTD |
| TOP2A |
N-[[2-[2-(Diethylamino)ethyl]-2H-[1]-benzothiopyrano[4,3,2-cd]indazol-5-yl]methyl]methanesulfonamide |
NA |
NA |
NA |
230000 |
NA |
NA |
TTD |
| TOP2A |
1-Cyclopropyl-6,8-difluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-3-quinolincarboxylic |
NA |
NA |
NA |
150000 |
NA |
NA |
BindingDB|TTD |
| TOP2A |
N,N-diethyl-2-[10-(methylaminomethyl)-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9,11,13(16)-heptaen-14-yl]ethanamine |
NA |
NA |
NA |
220000 |
NA |
NA |
TTD |
| TOP2A |
[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-acetic acid |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
1-[2-(Diethylamino)ethylamino]-7-methoxy-4-(methylaminomethyl)thioxanthen-9-one |
NA |
NA |
NA |
500000 |
NA |
NA |
TTD |
| TOP2A |
2-[(8R,9S,13S,14S,17R)-3,17-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-N-[6-[[2-(5,11-dimethylpyrido[4,3-b]carbazol-6-yl)acetyl]amino]hexyl]acetamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
N-[6-[[2-[(8R,9S,13S,14S,17R)-3,17-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]acetyl]amino]hexyl]-5,11-dimethyl-6H-pyrido[4,3-b]carbazole-9-carboxamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |