| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TOP2A |
(3E)-3-[(4-nitrophenyl)methylidene]-1-benzofuran-2-one |
NA |
400000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
11-Fluoro-10-(4-methylpiperazin-1-yl)-5-nitro-14-oxo-8-oxa-1-azatetracyclo[7.7.1.02,7.013,17]heptadeca-2(7),3,5,9(17),10,12,15-heptaene-15-carboxylic acid |
NA |
250000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
(2R)-6-(2,6-dimethylpyridin-4-yl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid |
NA |
NA |
NA |
540000 |
NA |
NA |
TTD |
| TOP2A |
(2S)-6-(2,6-dimethylpyridin-4-yl)-2-ethyl-7-fluoro-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid |
NA |
NA |
NA |
420000 |
NA |
NA |
BindingDB|TTD |
| TOP2A |
(4'R,6'S,7'S)-17'-fluoro-4',6'-dimethyl-13'-[(5R)-5-methyl-2-oxo-1,3-thiazolidin-3-yl]spiro[1,3-diazinane-5,8'-5,15-dioxa-2,14-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(17),10,12(16),13-tetraene]-2,4,6-trione |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
(4'R,6'S,7'S)-17'-fluoro-13'-[(5R)-5-(methoxymethyl)-2-oxo-1,3-thiazolidin-3-yl]-4',6'-dimethylspiro[1,3-diazinane-5,8'-5,15-dioxa-2,14-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(17),10,12(16),13-tetraene]-2,4,6-trione |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
(4'R,6'S,7'S)-17'-fluoro-4',6'-dimethyl-13'-[(5S)-5-methyl-2-oxo-1,3-thiazolidin-3-yl]spiro[1,3-diazinane-5,8'-5,15-dioxa-2,14-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(17),10,12(16),13-tetraene]-2,4,6-trione |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
(4'R,6'S,7'S)-13'-[(5S)-5-ethyl-2-oxo-1,3-thiazolidin-3-yl]-17'-fluoro-4',6'-dimethylspiro[1,3-diazinane-5,8'-5,15-dioxa-2,14-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(17),10,12(16),13-tetraene]-2,4,6-trione |
NA |
128400 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
(4'R,6'S,7'S)-17'-fluoro-4',6'-dimethyl-13'-[(4S)-4-methyl-2-oxo-1,3-thiazolidin-3-yl]spiro[1,3-diazinane-5,8'-5,15-dioxa-2,14-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(17),10,12(16),13-tetraene]-2,4,6-trione |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
(3E)-5-hydroxy-3-[(4-hydroxyphenyl)methylidene]-1-benzofuran-2-one |
NA |
400000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
7-(2,6-Dimethylpyridin-4-yl)-6,8-difluoro-1-(4-fluorophenyl)-4-oxoquinoline-3-carboxylic acid |
NA |
NA |
NA |
430000 |
NA |
NA |
TTD |
| TOP2A |
7-(2,6-Dimethylpyridin-4-yl)-1-ethyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acid |
NA |
NA |
NA |
110000 |
NA |
NA |
BindingDB|TTD |
| TOP2A |
7-(2,6-Dimethylpyridin-4-yl)-6,8-difluoro-1-(2-fluoroethyl)-4-oxoquinoline-3-carboxylic acid |
NA |
NA |
NA |
530000 |
NA |
NA |
TTD |
| TOP2A |
7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxo-1H-quinoline-3-carboxylic acid |
NA |
NA |
NA |
300000 |
NA |
NA |
TTD |
| TOP2A |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-2-methyl-4-oxoquinoline-3-carboxylic acid |
NA |
NA |
NA |
260000 |
NA |
NA |
TTD |
| TOP2A |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxo-2-phenylquinoline-3-carboxylic acid |
NA |
NA |
NA |
220000 |
NA |
NA |
TTD |
| TOP2A |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-2-phenylquinolin-4-one |
NA |
NA |
NA |
240000 |
NA |
NA |
TTD |
| TOP2A |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxo-5-phenylsulfanylquinoline-3-carboxylic acid |
NA |
NA |
NA |
420000 |
NA |
NA |
TTD |
| TOP2A |
{4-Amino-6-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}methyl morpholine-4-carbodithioate |
NA |
229000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
4-[(3-chlorophenyl)methylsulfanyl]-6-[[4-(hydroxymethyl)phenyl]methylsulfanyl]-1H-1,3,5-triazin-2-one |
NA |
126600 |
NA |
NA |
NA |
NA |
TTD |