| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TSPO |
Lorazepam |
NA |
285759000|285759054.3 |
NA |
NA |
NA |
NA |
PubChem|TTD |
| TSPO |
2,3-Dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-7-carboxaldehyde |
NA |
23280912.58 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
5-Phenyl-7-vinyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |
NA |
41686938.35 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
7,8-Dichloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |
NA |
25003453.62 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
7-Fluoro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one |
NA |
135207256.3 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
8-Chloro-5-(2-fluoro-phenyl)-7-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |
NA |
71449632.61 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
3,7-Dichloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one |
NA |
188799134.9 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
1,7-dichloro-3-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one |
NA |
20417379.45 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
5-(2-Fluorophenyl)-8-methyl-1,3-dihydro-1,4-benzodiazepin-2-one |
NA |
52601726.64 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
1-tert-butyl-5-(2-fluorophenyl)-7-nitro-3H-1,4-benzodiazepin-2-one |
NA |
3334264.13 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
7-Fluoro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one |
NA |
58884365.54 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
Meclonazepam, (R)-isomer |
NA |
833681184.6 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
(3R)-7-chloro-5-(2-fluorophenyl)-3-methyl-1,3-dihydro-1,4-benzodiazepin-2-one |
NA |
285759054.3 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
7-Chloro-5-(2-chloro-6-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one |
NA |
333426412.8 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
7-Azido-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one |
NA |
188799134.9 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
Difludiazepam |
NA |
243781081.8 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
5-(2,6-Difluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one |
NA |
52601726.64 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
Nitrazepam |
NA |
100000000 |
NA |
NA |
NA |
NA |
PubChem|TTD |
| TSPO |
Norfludiazepam |
NA |
500034535 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
Oxazepam |
NA |
55590400|55590425.73 |
NA |
NA |
NA |
NA |
PubChem|TTD |