| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TRPV6 |
Bis(2-methoxyphenyl)borinic acid |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TRPV6 |
2,2-Bis(2-methoxyphenyl)-1-oxa-3-azonia-2-boranuidacyclopentane |
NA |
412300 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TSG101 |
(4S)-5-amino-4-[[(2S)-4-carboxy-2-[[(2S,4S)-1-[1-[(2S)-2-[[(2S,3R)-2-[[(2S)-1-[(2S)-4-carboxy-2-[[(2S)-1-[5-[(3',6'-dihydroxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-yl)carbamothioylamino]pentanoyl]pyrrolidine-2-carbonyl]amino]butanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]propanoyl]piperidine-2-carbonyl]-4-[(Z)-(3,4-dimethoxyphenyl)methylideneamino]oxypyrrolidine-2-carbonyl]amino]butanoyl]amino]-5-oxopentanoic acid |
NA |
114000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TSG101 |
(4S)-5-amino-4-[[(2S)-4-carboxy-2-[[(2S,4S)-1-[1-[(2S)-2-[[(2S,3R)-2-[[(2S)-1-[(2S)-4-carboxy-2-[[(2S)-1-[5-[(3',6'-dihydroxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-yl)carbamothioylamino]pentanoyl]pyrrolidine-2-carbonyl]amino]butanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]propanoyl]piperidine-2-carbonyl]-4-[(Z)-(2,3,4,5,6-pentafluorophenyl)methylideneamino]oxypyrrolidine-2-carbonyl]amino]butanoyl]amino]-5-oxopentanoic acid |
NA |
139000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TSG101 |
(4S)-5-amino-4-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S,3R)-2-[[(2S)-1-[2-[[(2S)-1-[5-[(3',6'-dihydroxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-yl)carbamothioylamino]pentanoyl]pyrrolidine-2-carbonyl]-prop-2-enylamino]acetyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]-prop-2-enylamino]acetyl]amino]-5-oxopentanoic acid |
NA |
NA |
590000 |
NA |
NA |
NA |
BindingDB |
| TSG101 |
3-[(3S,9S,12S,15S,32S,35S)-30-(2-amino-2-oxoethyl)-22-[(2S)-1-[5-[(3',6'-dihydroxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-yl)carbamothioylamino]pentanoyl]pyrrolidine-2-carbonyl]-12-[(1R)-1-hydroxyethyl]-9-methyl-2,8,11,14,20,31,34-heptaoxo-1,7,10,13,19,22,30,33-octazatetracyclo[33.3.0.03,7.015,19]octatriacont-27-en-32-yl]propanoic acid |
NA |
NA |
108000 |
NA |
NA |
NA |
BindingDB |
| TSG101 |
3-[(3S,9S,12S,15S,34S,37S)-32-(2-amino-2-oxoethyl)-22-[(2S)-1-[5-[(3',6'-dihydroxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-yl)carbamothioylamino]pentanoyl]pyrrolidine-2-carbonyl]-12-[(1R)-1-hydroxyethyl]-9-methyl-2,8,11,14,20,33,36-heptaoxo-1,7,10,13,19,22,32,35-octazatetracyclo[35.3.0.03,7.015,19]tetracont-29-en-34-yl]propanoic acid |
NA |
NA |
112000 |
NA |
NA |
NA |
BindingDB |
| TSG101 |
(4S)-5-amino-4-[[2-[(3S,9S,12S,15S,24Z,29S)-22-[(2S)-1-[5-[(3',6'-dihydroxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-yl)carbamothioylamino]pentanoyl]pyrrolidine-2-carbonyl]-12-[(1R)-1-hydroxyethyl]-9-methyl-2,8,11,14,20,28-hexaoxo-1,7,10,13,19,22,27-heptazatetracyclo[27.3.0.03,7.015,19]dotriacont-24-en-27-yl]acetyl]amino]-5-oxopentanoic acid |
NA |
NA |
218000 |
NA |
NA |
NA |
BindingDB |
| TSG101 |
(4S)-5-amino-4-[[2-[(3S,9S,12S,15S,25Z,30S)-22-[(2S)-1-[5-[(3',6'-dihydroxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-yl)carbamothioylamino]pentanoyl]pyrrolidine-2-carbonyl]-12-[(1R)-1-hydroxyethyl]-9-methyl-2,8,11,14,20,29-hexaoxo-1,7,10,13,19,22,28-heptazatetracyclo[28.3.0.03,7.015,19]tritriacont-25-en-28-yl]acetyl]amino]-5-oxopentanoic acid |
NA |
NA |
171000 |
NA |
NA |
NA |
BindingDB |
| TSG101 |
3-[(3S,9S,12S,15S,21S,29Z,39S,42S)-37-(2-amino-2-oxoethyl)-39-(2-carboxyethyl)-25-[5-[(3',6'-dihydroxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-yl)carbamothioylamino]pentanoyl]-12-[(1R)-1-hydroxyethyl]-9-methyl-2,8,11,14,20,23,38,41-octaoxo-1,7,10,13,19,22,25,37,40-nonazatetracyclo[40.3.0.03,7.015,19]pentatetracont-29-en-21-yl]propanoic acid |
NA |
NA |
106000 |
NA |
NA |
NA |
BindingDB |
| TSHR |
Silybin |
NA |
NA |
NA |
NA |
121600 |
NA |
PubChem |
| TSHR |
Niclosamide |
NA |
NA |
NA |
NA |
239341 |
NA |
PubChem |
| TSHR |
Thioridazine Hydrochloride |
NA |
NA |
NA |
NA |
305133 |
NA |
PubChem |
| TSPO |
7-Ethyl-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one |
NA |
27797132.68 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
7,8-Dichloro-5-(2-fluoro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one |
NA |
277971326.8 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
5-(2-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one |
NA |
263026799.2 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-7-iodo-1-methyl- |
NA |
345143739.3 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
7-Chloro-5-(2,6-dichloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one |
NA |
142889395.9 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
Ro 11-6893 |
NA |
142889395.9 |
NA |
NA |
NA |
NA |
TTD |
| TSPO |
1,4-Benzodiazpin-2-one,5-(2-F PH) |
NA |
47643098.68 |
NA |
NA |
NA |
NA |
TTD |