| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TYK2 |
1-(2-Aminoethyl)-2-piperidin-4-ylbenzimidazole-5-carboxamide |
NA |
759500 |
NA |
NA |
NA |
NA |
BindingDB |
| TYK2 |
N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
2-methoxy-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]ethanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
N-(cyclopropylmethyl)-1-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
1-cyclobutyl-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]cyclopropanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
4-[[3-[[cyclopropyl(methyl)sulfamoyl]amino]cyclobutyl]-methylamino]-7H-pyrrolo[2,3-d]pyrimidine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
1-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]-N-propylmethanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
3-N-(ethylsulfamoyl)-1-N-methyl-1-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclobutane-1,3-diamine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
N-ethyl-1-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
3-methoxy-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]butane-1-sulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
4-[[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]sulfamoylamino]butanenitrile |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
4-[[3-[[ethyl(methyl)sulfamoyl]amino]cyclobutyl]-methylamino]-7H-pyrrolo[2,3-d]pyrimidine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]-1-phenylmethanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
3-N-(cyclopropylsulfamoyl)-1-N-methyl-1-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclobutane-1,3-diamine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
4,4,4-trifluoro-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]butane-1-sulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]piperidine-1-sulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
N-[3-(cyclopropylsulfonylmethyl)cyclobutyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
N-butyl-1-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |