| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TYK2 |
N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]ethanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
N-(cyclopropylmethyl)-N-methyl-1-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
4-fluoro-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]benzenesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
N-methyl-N-[3-(pyrrolidin-1-ylsulfonylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
3,3,3-trifluoro-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]benzenesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
1-N-methyl-3-N-(propylsulfamoyl)-1-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclobutane-1,3-diamine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
3-cyano-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
N-[3-(ethylsulfonylmethyl)cyclobutyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
N-[(2R,3S,4S,6S)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide |
250000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| TYK2 |
Ruxolitinib |
NA |
200000 |
NA |
NA |
NA |
NA |
PubChem |
| TYK2 |
Baricitinib |
NA |
200000 |
NA |
NA |
NA |
NA |
PubChem |
| TYK2 |
Sunitinib |
1600000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| TYK2 |
N-methyl-N-[3-(propylsulfonylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
N-[3-(butylsulfonylmethyl)cyclobutyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
Abrocitinib |
NA |
200000 |
NA |
NA |
NA |
NA |
PubChem|TTD |
| TYK2 |
2,2,2-trifluoro-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]ethanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
2-Methyl-N-[cis-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]-1-(oxetan-3-yl)methanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
1-cyclopropyl-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |