| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TYK2 |
1-cyclopropyl-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]azetidine-3-sulfonamide |
NA |
4910000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYK2 |
3-N-(cyclopropylmethylsulfamoyl)-1-N-methyl-1-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclobutane-1,3-diamine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
4-[[3-[[2-cyanoethyl(methyl)sulfamoyl]amino]cyclobutyl]-methylamino]-7H-pyrrolo[2,3-d]pyrimidine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYK2 |
Tofacitinib |
620000|NA |
NA|200000 |
NA |
NA |
NA |
NA |
BindingDB|PubChem |
| TYMP |
1-benzyl-5''-O-benzylinosine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMP |
5-Bromo-6-(2-nitro-imidazol-1-ylmethyl)-1H-pyrimidine-2,4-dione |
NA |
160000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMP |
6-[(2-nitroimidazol-1-yl)methyl]-1H-pyrimidine-2,4-dione |
NA |
257700 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMP |
5-Chloro-6-(2-nitro-imidazol-1-ylmethyl)-1H-pyrimidine-2,4-dione |
NA |
115000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMP |
5-Chloro-6-(4-nitro-imidazol-1-ylmethyl)-1H-pyrimidine-2,4-dione |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMP |
4-Amino-1-(2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-ylmethyl)-3H-imidazol-1-ium |
NA |
143000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMP |
5-Bromo-6-(4-nitro-imidazol-1-ylmethyl)-1H-pyrimidine-2,4-dione |
NA |
181000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMP |
6-(4-Nitro-imidazol-1-ylmethyl)-1H-pyrimidine-2,4-dione |
NA |
500000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMP |
[(2S,3R,4R,5R,6R)-2-[2-(benzoyloxymethyl)-4-hydroxyphenoxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] 4-hydroxybenzoate |
NA |
225670 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMP |
5''-O-trityl-2'',3''-secoinosine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMP |
5-amino-1-(5-O-trityl-beta-D-ribofuranosyl)imidazole-4-(N-methyl)carboxamide |
NA |
137000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMP |
((2S,3aR,4R,6R,6aS)-6-(hydroxymethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-hexahydrofuro[3,4-b]furan-2-yl)methylphosphonic acid |
500000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMP |
6-(phenethylamino)pyrimidine-2,4(1H,3H)-dione |
NA |
148000|200000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMP |
6-Benzylamino-1H-pyrimidine-2,4-dione |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMP |
6-(3-Phenyl-propylamino)-1H-pyrimidine-2,4-dione |
NA |
125000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMP |
6-Amino-1H-thieno[3,2-d]pyrimidine-2,4-dione |
300000 |
NA |
NA |
NA |
NA |
NA |
TTD |