| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TYMS |
7-chloro-3-methyl-5,6-dihydro-2H-benzo[f]quinazolin-1-one |
NA |
192800 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
3-amino-7-methoxy-5,6-dihydro-2H-benzo[f]quinazolin-1-one |
NA |
146000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
3-amino-7-bromo-5,6-dihydro-2H-benzo[f]quinazolin-1-one |
NA |
154000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
3-amino-8-methoxy-5,6-dihydro-2H-benzo[f]quinazolin-1-one |
NA |
220000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
3-amino-8-fluoro-5,6-dihydro-2H-benzo[f]quinazolin-1-one |
NA |
107000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
3-amino-8-fluoro-7-nitro-2H-benzo[f]quinazolin-1-one |
NA |
552000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
7-iodo-3-methyl-5,6-dihydro-2H-benzo[f]quinazolin-1-one |
NA |
154000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-phosphono-butyric acid |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-phosphono-butyric acid |
NA |
4200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
5-Amino-2-{4-[(2-amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanoic acid |
NA |
470000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-sulfo-butyric acid |
NA |
2100000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
diethyl 2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[3,2-d]pyrimidin-6-yl)methyl-nitrosoamino]benzoyl]amino]pentanedioate |
150000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid |
NA |
5000000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
2-[4-(2-Amino-4-oxo-4,4b,5,7,8,8a,9,10-octahydro-3H-1,3,6,10-tetraaza-phenanthren-6-yl)-benzoylamino]-pentanedioic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
(R)-2-{4-[(2-Amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoylamino}-pentanedioic acid |
NA |
180000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
3-amino-10-chloro-5,6-dihydro-2H-benzo[f]quinazolin-1-one |
NA |
770000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
2-{4-[(2-Amino-5-{1-[4-hydroxy-5-(hydroxy-methoxy-phosphoryloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl}-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[3,2-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid |
120000|700000 |
NA |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMS |
2-[4-({2-Amino-5-[1-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl]-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[3,2-d]pyrimidin-6-ylmethyl}-amino)-benzoylamino]-pentanedioic acid |
150000|240000 |
NA |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMS |
|
NA |
300000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
|
NA |
4200000 |
NA |
NA |
NA |
NA |
BindingDB |