| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TYMS |
N-(4-(N-((2,4-Diaminofuro(2,3-d)pyrimidin-5-yl)methyl)amino)benzoyl)glutamic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
Furo[2,3d]Pyrimidine Antifolate |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
1,1-Bis(4-hydroxyphenyl)benzo[e]isobenzofuran-3-one |
132000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
1,1-Bis(4-hydroxy-3-iodo-phenyl)benzo[e]isobenzofuran-3-one |
245000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
1,1-Bis(3-bromo-4-hydroxy-phenyl)benzo[e]isobenzofuran-3-one |
132000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
1,1-Bis(3,5-dibromo-4-hydroxy-phenyl)benzo[e]isobenzofuran-3-one |
245000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
3,3-Bis(3-fluoro-4-hydroxy-phenyl)benzo[g]isobenzofuran-1-one |
132000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
Phenolnaphthalein derivative, 2 |
245000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
Phenolnaphthalein derivative, 3 |
245000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
(2S)-5-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2R)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(1S)-1-carboxy-4-(diaminomethylideneamino)butyl]amino]-1,5-dioxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]-5-oxopentanoic acid |
NA |
NA |
120000 |
NA |
NA |
NA |
BindingDB |
| TYMS |
Naphthalic anhydride, 3-nitro- |
206000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
1,8-Naphthalein derivative, 9 |
132000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[1-(furan-2-ylmethyl)-2,5-dimethyl-1H-pyrrol-3-yl]ethanone |
NA |
115000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
6-[(2-hydroxyethyl)thio]-1H,3H-naphtho[1,8-cd]pyran-1,3-dione |
474000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
4-[(5-Thiophen-2-ylthiophen-2-yl)methylideneamino]benzoic acid |
NA |
240000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
3,3-Diphenyl-1H,3H-naphtho(1,8-cd)pyran-1-one |
309000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
2-[[4-[(2,4-Diaminofuro[2,3-d]pyrimidin-5-yl)methyl-methyl-amino]benzoyl]amino]pentanedioic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
Benzyl (1-(2-((2-hydroxyethyl)amino)ethyl)-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonylcarbamate |
NA |
619000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMS |
2-Amino-3-[4-[5-(dimethylamino)naphthalen-1-yl]sulfonyloxyphenyl]propanoic acid |
NA |
771000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
Phenolnaphthalein derivative, 1 |
402000 |
NA |
NA |
NA |
NA |
NA |
TTD |