| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TYMS |
2,4-Diamino-5-methyl-6-(2''-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
2,4-Diamino-5-methyl-6-(3''-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
6-(3,4-Dimethoxyphenyl)sulfanyl-5-methylfuro[2,3-d]pyrimidine-2,4-diamine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
5-Methyl-6-(2-methyl-6-propan-2-ylphenyl)sulfanylfuro[2,3-d]pyrimidine-2,4-diamine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
2-[[4-[(2,4-Diaminofuro[2,3-d]pyrimidin-5-yl)methylamino]benzoyl]amino]pentanedioic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
1,8-Naphthalein derivative, 11 |
120000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
(2S)-2-[[4-[(E)-1-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)prop-1-en-2-yl]benzoyl]amino]pentanedioic acid |
NA |
360000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
2-(4-Imidazol-1-ylphenyl)-4-methylisoindole-1,3-dione |
206000 |
NA |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMS |
|
NA |
260000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
2-(2,5-Dimethyl-1H-indol-3-YL)-N'-[(1E)-1-(thiophen-2-YL)ethylidene]acetohydrazide |
NA |
160000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid |
NA |
290000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
Flavin Mononucleotide |
NA |
500000 |
NA |
NA |
NA |
NA |
PubChem|TTD |
| TYMS |
3-phenyl-N-(thiophen-2-ylmethyl)-1,2,4-oxadiazole-5-carboxamide |
NA |
115000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
Ethyl 4-[2-(2,3-dihydroindol-1-yl)-2-oxoethyl]furo[3,2-b]pyrrole-5-carboxylate |
NA |
140000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
N'-[(E)-[4-(2-amino-2-oxoethoxy)phenyl]methylideneamino]-N-(2-methoxy-5-methylphenyl)oxamide |
NA |
112000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMS |
3-chloro-N-(2,4-dioxo-3-oxatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8,10-pentaen-7-yl)-1-benzothiophene-2-carboxamide |
411000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
(E)-3-(2-chlorophenyl)-N-(2,4-dioxo-3-oxatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8,10-pentaen-7-yl)prop-2-enamide |
616000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
(E)-N-(2,4-dioxo-3-oxatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8,10-pentaen-7-yl)-3-[3-(trifluoromethyl)phenyl]prop-2-enamide |
206000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
3-(2-chlorophenyl)-N-(2,4-dioxo-3-oxatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8,10-pentaen-7-yl)-5-methyl-1,2-oxazole-4-carboxamide |
826000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
4-amino-N-(2,4-dioxo-3-oxatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8,10-pentaen-7-yl)benzamide |
823000 |
NA |
NA |
NA |
NA |
NA |
TTD |