| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TYMS |
|
NA |
2100000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
|
150000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
2-({4-[2-(4,6-Diamino-furo[2,3-b]pyridin-3-yl)-ethyl]-benzoyl}-methyl-amino)-pentanedioic acid |
NA |
220000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMS |
2-({4-[2-(4,6-Diamino-furo[2,3-b]pyridin-3-yl)-1-methyl-ethyl]-benzoyl}-methyl-amino)-pentanedioic acid |
NA |
360000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
2-({4-[1-(4,6-Diamino-furo[2,3-b]pyridin-3-ylmethyl)-propyl]-benzoyl}-methyl-amino)-pentanedioic acid |
NA |
220000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMS |
|
NA |
180000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
|
NA |
360000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
(S)-2-{[5-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethoxy]-hydroxy-phosphorylamino}-3-phenyl-propionic acid methyl ester |
NA |
190000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
2'-Deoxy-2',2'-difluoro-5'-uridylic acid |
432800 |
NA |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMS |
Tosyl-D-Proline |
1100000 |
NA |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMS |
N,O-Didansyl-L-Tyrosine |
NA |
119000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
(2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioic acid |
NA |
110000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
2-Phenylimino-2H-acenaphthylen-1-one |
309000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
2,4-Diamino-5-methyl-6-(1-naphthylthio)furo[2,3-d]pyrimidine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
2,4-Diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]pyrimidine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
6-(2,6-Dimethylphenyl)sulfanyl-5-methylfuro[2,3-d]pyrimidine-2,4-diamine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
6-(2,6-Dichlorophenyl)sulfanyl-5-methylfuro[2,3-d]pyrimidine-2,4-diamine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
6-(2,5-Dimethoxyphenyl)sulfanyl-5-methylfuro[2,3-d]pyrimidine-2,4-diamine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
2,4-Diamino-5-methyl-6-(4''-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
5-Methyl-6-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]sulfanylfuro[2,3-d]pyrimidine-2,4-diamine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |