| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TYMS |
N-(2,4-dioxo-3-oxatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8,10-pentaen-7-yl)-4-(trifluoromethyl)benzamide |
206000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
H-Leu-Ser-Cys-Gln-Leu-Tyr-Gln-Arg-OH |
NA |
300000|500000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
H-Leu-Ser-Cys-D-Gln-Leu-Tyr-Gln-Arg-OH |
NA |
152000|300000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMS |
4-Aminonaphthalene-1,8-dicarboxylic anhydride |
160000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
N-(1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)thiophene-2-carboxamide |
NA |
160000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYMS |
[(2R,3S,5R)-3-hydroxy-5-[5-(4-hydroxyphenyl)-2,4-dioxopyrimidin-1-yl]oxolan-2-yl]methyl dihydrogen phosphate |
134100 |
NA |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMS |
[(2R,3S,5R)-5-[5-(4-cyanophenyl)-2,4-dioxopyrimidin-1-yl]-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate |
114200 |
NA |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMS |
[(2R,3S,5R)-5-[5-(4-carbamoylphenyl)-2,4-dioxopyrimidin-1-yl]-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate |
119400 |
NA |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMS |
4-[1-(4-Hydroxy-5-phosphonooxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-benzoic acid methyl ester |
102500 |
NA |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYMS |
1-(Dicyanomethylene)acenaphthen-2-one |
309000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
2-{4-[2-(2,4-Diamino-furo[2,3-d]pyrimidin-5-yl)-1-methyl-ethyl]-benzoylamino}-pentanedioic acid |
NA |
360000 |
NA |
NA |
NA |
NA |
TTD |
| TYMS |
N-[4-[2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid |
NA |
200000|220000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYR |
Phenylethyl resorcinol |
NA |
130000|131000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYR |
Fortuneanoside B |
NA |
2210000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYR |
Fortuneanoside E |
NA |
140000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYR |
(1E,4E)-1,5-bis(4-fluorophenyl)penta-1,4-dien-3-one |
NA |
250000 |
NA |
NA |
NA |
NA |
TTD |
| TYR |
5-[(Z)-(4,6-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-1-hydroxypyridin-2-one |
NA |
119000 |
NA |
NA |
NA |
NA |
BindingDB |
| TYR |
2-(2,4-Dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methyl-2-oxobut-3-enyl)pyrano[2,3-h]chromen-4-one |
NA |
290000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TYR |
2,6-Bis-(4-chloro-benzylidene)-cyclohexanone |
NA |
250000 |
NA |
NA |
NA |
NA |
TTD |
| TYR |
(2S)-2-amino-3-(3,4-dihydroxyphenyl)-N-[5-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]pentyl]propanamide |
NA |
112700 |
NA |
NA |
NA |
NA |
BindingDB |