| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| AKT1 |
4-[5-[(E)-(2-amino-3,7-dicyano-4,6-dimethylcyclopenta[b]pyridin-5-ylidene)methyl]furan-2-yl]benzoic acid |
NA |
126000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
4-Phenylpyrazole |
NA |
135000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
N-(5-nitro-1,3-thiazol-2-yl)-2-[[5-(5,6,7,8-tetrahydronaphthalen-2-yloxymethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide |
NA |
138330 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}pentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]-3-(1H-indol-3-yl)propanamido]-3-phenylpropanoic acid |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}pentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]-3-phenylpropanamido]-3-phenylpropanoic acid |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}pentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]-3-(1H-imidazol-5-yl)propanamido]-3-phenylpropanoic acid |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}pentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]-3-methylbutanamido]-3-phenylpropanoic acid |
NA |
445000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}pentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]propanamido]-3-phenylpropanoic acid |
NA |
409000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
(2S)-2-[(2R)-2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}pentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]-3-sulfanylpropanamido]-3-phenylpropanoic acid |
NA |
241000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-[2-(carboxyamino)acetamido]pentanoyl]pyrrolidin-2-yl]formamido}pentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]-3-carbamoylpropanamido]-3-phenylpropanoic acid |
NA |
229000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
(2S)-N-[(1S,2R)-1-{[(1S,2R)-1-{[(1S)-1-{[(1S)-1-(benzylcarbamoyl)-2-phenylethyl]carbamoyl}-2-methylpropyl]carbamoyl}-2-hydroxypropyl]carbamoyl}-2-hydroxypropyl]-5-carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}pentanamide |
NA |
239000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
(2S)-N-[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-(benzylcarbamoyl)-2-phenylethyl]carbamoyl}-2-methylpropyl]carbamoyl}ethyl]carbamoyl}ethyl]-5-carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}pentanamide |
NA |
438000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}-N-(4-{[(1S)-1-{[(1S)-1-{[3-(3-acetamidophenoxy)propyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-methylpropyl]carbamoyl}phenyl)pentanamide |
NA |
322000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}-N-(4-{[(1S)-2-methyl-1-{[(1S)-2-phenyl-1-{[2-(piperidin-1-yl)ethyl]carbamoyl}ethyl]carbamoyl}propyl]carbamoyl}phenyl)pentanamide |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
(2S)-N-[(1S)-1-(benzylcarbamoyl)-2-phenylethyl]-2-({4-[(2S)-2-{[(2S)-1-[(2S)-2-(2-acetamidoacetamido)propanoyl]pyrrolidin-2-yl]formamido}propanamido]phenyl}formamido)-3-methylbutanamide |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
(2S)-5-carbamimidamido-2-acetamido-N-(4-{[(1S)-2-methyl-1-{[(1S)-1-{[(4-pentylphenyl)methyl]carbamoyl}-2-phenylethyl]carbamoyl}propyl]carbamoyl}phenyl)pentanamide |
NA |
104000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
(2S)-N-(4-{[(1S)-1-{[(1S)-1-(benzylcarbamoyl)-2-phenylethyl]carbamoyl}-2-methylpropyl]carbamoyl}phenyl)-5-carbamimidamido-2-acetamidopentanamide |
NA |
119000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
(2S)-5-carbamimidamido-2-acetamido-N-(4-{[(1S)-1-{[(1S)-1-(hexylcarbamoyl)-2-phenylethyl]carbamoyl}-2-methylpropyl]carbamoyl}phenyl)pentanamide |
NA |
163000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
N-(4-{[(1S)-1-{[(1S)-1-(benzylcarbamoyl)-2-phenylethyl]carbamoyl}-2-methylpropyl]carbamoyl}phenyl)-5-carbamimidamidopentanamide |
NA |
193000 |
NA |
NA |
NA |
NA |
TTD |
| AKT1 |
N-[(S)-1-((S)-1-benzylcarbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-4-(2-guanidino-ethylamino)-benzamide |
NA |
390000 |
NA |
NA |
NA |
NA |
TTD |