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Drugs And Genes
Negative Drug Target Genes
GENE_SYMBOL DRUG_NAME Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) Potency (nM) AC50 (nM) Datasource
JAK2 4-[[4-Amino-6-[5-(hydroxymethyl)furan-2-yl]-1,3,5-triazin-2-yl]amino]benzonitrile NA NA 122300 NA NA NA BindingDB
JAK2 (1R,2R,5S)-5-hydroxy-2-[4-oxo-3-[4-(trifluoromethyl)anilino]-3,3a,5,6,7,7a-hexahydro-2H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexane-1-carbonitrile NA 117000 NA NA NA NA BindingDB
JAK2 (1S,2S,5R)-2-[3-(4-chlorophenyl)imino-4-oxo-2,3a-dihydropyrazolo[4,3-c]pyridin-1-yl]-5-[[(1S)-1-cyclopropylethyl]amino]cyclohexane-1-carbonitrile NA 122000 NA NA NA NA BindingDB
JAK2 (1R,2R,5R)-2-[3-(4-chlorophenyl)imino-4-oxo-2,3a-dihydropyrazolo[4,3-c]pyridin-1-yl]-5-[[(1S)-1-cyclopropylethyl]amino]cyclohexane-1-carbonitrile NA 525000 NA NA NA NA BindingDB
JAK2 (1S,2S,5R)-2-[3-(4-chloro-3-fluoroanilino)-4-oxo-3,3a,5,6,7,7a-hexahydro-2H-pyrazolo[4,3-c]pyridin-1-yl]-5-[[(1S)-1-cyclopropylethyl]amino]cyclohexane-1-carbonitrile NA 113000 NA NA NA NA BindingDB
JAK2 (1R,2R,5S)-5-(azetidin-1-yl)-2-[4-oxo-3-[4-(trifluoromethyl)anilino]-3,3a,5,6,7,7a-hexahydro-2H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexane-1-carbonitrile NA 660000 NA NA NA NA BindingDB
JAK2 (1R,2R,5R)-5-(azetidin-1-yl)-2-[4-oxo-3-[4-(trifluoromethyl)anilino]-3,3a,5,6,7,7a-hexahydro-2H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexane-1-carbonitrile NA 940000 NA NA NA NA BindingDB
JAK2 (1S,2S,5R)-5-[[(1S)-1-cyclopropylethyl]amino]-2-[4-oxo-3-[4-(trifluoromethyl)anilino]-3,3a,5,6,7,7a-hexahydro-2H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexane-1-carbonitrile NA 106000 NA NA NA NA BindingDB
JAK2 (1R,2R,5R)-5-[[(1S)-1-cyclopropylethyl]amino]-2-[4-oxo-3-[4-(trifluoromethyl)anilino]-3,3a,5,6,7,7a-hexahydro-2H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexane-1-carbonitrile NA 580000 NA NA NA NA BindingDB
JAK2 (1S,2S,5R)-5-[[(1S)-1-cyclopropylethyl]amino]-2-[4-oxo-3-[4-(trifluoromethoxy)anilino]-3,3a,5,6,7,7a-hexahydro-2H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexane-1-carbonitrile NA 233000 NA NA NA NA BindingDB
JAK2 US11279703, Table 6.217 NA 1000000 NA NA NA NA BindingDB
JAK2 N-(pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide NA 133600 NA NA NA NA BindingDB|TTD
JAK2 6-[[5-(cyclopentylmethylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]-2-N-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine NA NA 149000 NA NA NA BindingDB
JAK2 6-bromo-1H-indazol-3-amine NA 131000 NA NA NA NA BindingDB|TTD
JAK2 Dasatinib 1000000 NA NA NA NA NA BindingDB
JAK2 3-[1-(4-Chlorobenzyl)-1h-indol-3-yl]-n-(4-nitrophenyl)propanamide NA 106700 NA NA NA NA BindingDB|TTD
JAK2 Src kinase inhibitor PP2 NA 50000000 NA NA NA NA TTD
JAK2 (3R)-1-[[1-[2-(3,5-dimethylanilino)pyrimidin-4-yl]-4-methylpyrrol-3-yl]methyl]pyrrolidin-3-ol NA 115300 NA NA NA NA BindingDB|TTD
JAK2 Sunitinib 410000 NA NA NA NA NA BindingDB
JAK2 Jnj-7706621 220000 NA NA NA NA NA BindingDB