| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| SHMT1 |
(2S)-2-[[2-[2-(2,4-dichlorophenyl)-1,3-thiazol-4-yl]acetyl]amino]-3-methylbutanoic acid;sulfane |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| SHMT1 |
(2S)-2-[[2-[2-(2,4-dichlorophenyl)-1,3-thiazol-4-yl]acetyl]amino]-4-methylsulfanylbutanoic acid;sulfane |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| SHMT1 |
(2S)-2-[[2-[2-(3-chlorophenyl)-1,3-thiazol-4-yl]acetyl]amino]-3-phenylpropanoic acid;sulfane |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| SHMT1 |
(2S)-3-(1H-indol-3-yl)-2-[[2-[2-(4-propan-2-ylphenyl)-1,3-thiazol-4-yl]acetyl]amino]propanoic acid;sulfane |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| SHMT1 |
(2S)-2-[[2-[2-(2-methoxyphenyl)-1,3-thiazol-4-yl]acetyl]amino]propanoic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| SHMT1 |
(2R)-phenyl(2-{2-[4-(propan-2-yl)phenyl]-1,3-thiazol-4-yl}acetamido)acetic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| SHMT1 |
N-{[2-(2-fluorophenyl)-1,3-thiazol-4-yl]acetyl}-L-alanine |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| SHMT1 |
(2S)-2-[[2-[2-(3-bromophenyl)-1,3-thiazol-4-yl]acetyl]amino]-3-phenylpropanoic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| SHMT1 |
N-({2-[4-(propan-2-yl)phenyl]-1,3-thiazol-4-yl}acetyl)-L-phenylalanine |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| SHMT1 |
(2R)-2-({2-[2-(4-Chlorophenyl)-1,3-thiazol-4-YL]acetyl}amino)-2-phenylethanoic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| SHMT1 |
(2S)-2-[[2-[2-(3-chlorophenyl)-1,3-thiazol-4-yl]acetyl]amino]-3-(1H-indol-3-yl)propanoic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| SHMT1 |
N-{[2-(2-chlorophenyl)-1,3-thiazol-4-yl]acetyl}-L-phenylalanine |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| SHMT1 |
N-({2-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-4-yl}acetyl)glycine |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| SHMT1 |
(2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioic acid |
185600 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| SHMT1 |
(2R)-({[2-(2,4-dichlorophenyl)-1,3-thiazol-4-yl]acetyl}amino)(phenyl)ethanoic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| SHMT1 |
N-{[2-(2,3-dichlorophenyl)-1,3-thiazol-4-yl]acetyl}glycine |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| SHMT1 |
N-{[2-(3-bromophenyl)-1,3-thiazol-4-yl]acetyl}phenylalanine |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| SHMT1 |
N-{[2-(2-methoxyphenyl)-1,3-thiazol-4-yl]acetyl}alanine |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| SI |
L-Ido-1-Deoxynojirimycin |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| SI |
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2S,3S,4R,5S)- |
NA |
220000 |
NA |
NA |
NA |
NA |
BindingDB |