| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| SIRT1 |
4-[[3-[(5-Carbamoylpyridin-3-yl)oxymethyl]phenyl]carbamoyl]benzoic acid |
NA |
142000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
5-[[3-(Naphthalene-1-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide |
NA |
192000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
5-[[3-[(3-Fluoro-4-phenylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide |
NA |
115000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
5-[[3-(Adamantane-1-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT1 |
Sirt2-IN-14 |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT1 |
5-[[3-[(2-Methylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide |
NA |
192000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
5-[[3-[(4-Thiophen-2-ylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide |
NA |
106000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT1 |
1,3-dimethyl-2,4-dioxo-N-[4-(pyridin-4-ylmethyl)phenyl]-1,2,3,4-tetrahydroquinazoline-6-sulfonamide |
NA |
6521000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
(2S)-6-acetamido-2-[[(2S)-6-[6-(1H-benzimidazol-2-ylsulfanyl)hexanoylamino]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamide |
NA |
187300 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
(2S)-6-acetamido-2-[[(2S)-6-[[2-[[2-[[2-(1,3-benzothiazol-2-ylsulfanyl)acetyl]amino]acetyl]amino]acetyl]amino]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamide |
NA |
116000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
Ac-Lys(Ac)-Lys(1)-Lys(Ac)-NH2.IAc-Gly-(1) |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT1 |
(2S)-6-acetamido-2-[[(2S)-2-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-[[2-[[5-[(E)-2-phenylethenyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]hexanoyl]amino]hexanamide |
NA |
149500 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
(2S)-6-acetamido-2-[[(2S)-6-[(2-benzylsulfanylacetyl)amino]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamide |
NA |
171000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
(2S)-6-acetamido-2-[[(2S)-6-[6-(1,3-benzoxazol-2-ylsulfanyl)hexanoylamino]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamide |
NA |
133100 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
(2S)-6-acetamido-2-[[(2S)-6-[6-[(6-amino-7H-purin-8-yl)sulfanyl]hexanoylamino]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamide |
NA |
900000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT1 |
N-[4-[[3-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]thiophene-2-carboxamide |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT1 |
7-[(3,5-Dimethyl-1,2-oxazol-4-yl)methylamino]-3-[(4-methoxynaphthalen-1-yl)methyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one |
NA |
129000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
ethyl N-[4-[(3-cyanophenyl)carbamoylamino]-2,2-dimethyl-3,4-dihydrochromen-6-yl]carbamate |
NA |
108700 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
methyl N-[4-[(3-cyanophenyl)carbamoylamino]-2,2-dimethyl-3,4-dihydrochromen-6-yl]carbamate |
NA |
109900 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-[4-(decylamino)-4-oxobutyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |