| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| SIRT1 |
(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-[4-oxo-4-(tridecylamino)butyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT1 |
(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-[4-(octylamino)-4-oxobutyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoic acid |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT1 |
[[(2R,3S,4S,5R)-4-amino-5-(3-carbamoylpyridin-1-ium-1-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate |
NA |
176200 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT1 |
SIRT2 inhibitor AF10 |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT1 |
benzyl N-[(2S)-1-anilino-6-(dodecylcarbamothioylamino)-1-oxohexan-2-yl]carbamate |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT1 |
SIRT6 activator 12q |
NA |
171200 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT1 |
N-[[4-[[[2-(2-bicyclo[2.2.1]heptanyl)-2-oxoethyl]amino]methyl]phenyl]methyl]-3-oxo-1,2-dihydroindene-1-carboxamide |
NA|120000 |
195000|NA |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT1 |
N-[2-[2-[2-[2-[[2-(2-bicyclo[2.2.1]heptanyl)-2-oxoethyl]amino]ethoxy]ethoxy]ethoxy]ethyl]-3-oxo-1,2-dihydroindene-1-carboxamide |
NA|645000 |
1040000|NA |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT1 |
N-[3-[[2-(2-bicyclo[2.2.1]heptanyl)-2-oxoethyl]amino]propyl]-3-oxo-1,2-dihydroindene-1-carboxamide |
NA|202000 |
330000|NA |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT1 |
N-[2-[2-[2-[[2-(2-bicyclo[2.2.1]heptanyl)-2-oxoethyl]amino]ethoxy]ethoxy]ethyl]-3-oxo-1,2-dihydroindene-1-carboxamide |
NA|183000 |
298000|NA |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT1 |
3-pyridin-3-yl-N-[6-[[2-(3,4,5-trimethoxyphenyl)acetyl]amino]hexyl]benzamide |
NA |
NA |
139000 |
NA |
NA |
NA |
BindingDB |
| SIRT1 |
3-pyridin-3-yl-N-[6-[(3-pyridin-3-ylbenzoyl)amino]hexyl]benzamide |
NA |
NA |
118000 |
NA |
NA |
NA |
BindingDB |
| SIRT1 |
2-benzoyl-1H-benzo[f]chromen-3(2H)-one |
NA |
112000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
SIRT5 inhibitor 7 |
NA |
112600 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT1 |
[4-(Benzyloxy)phenyl](4,6-dibromo-5-hydroxy-1-benzofuran-3-yl)methanone |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT1 |
Agk-2 |
NA |
135000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT1 |
6-Methoxy-1-(3-methoxy-prop-1-ynyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ol |
NA |
570000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
2-(3-(4-tert-butylphenyl)-1,2,4-oxadiazole-5-carbonyl)-N-(4-(trifluoromethyl)phenyl)hydrazinecarbothioamide |
NA |
325000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
3-[[3-(Naphthalen-1-yl)1,2,4-oxadiazole-5-carbonyl]amino]-1-[4-trifluoromethylphenyl]thiourea |
NA |
318000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
3-[[3-(tert-Butoxycarbonylamino-phenyl)-1,2,4-oxadiazole-5-carbonyl]amino]-1-(4-(trifluoromethyl)phenyl)thiourea |
NA |
168000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |