| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| SIRT1 |
N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]cyclopentanecarboxamide |
NA |
NA |
NA |
130000 |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
3-[[3-(4-Tertbutylphenyl)1,2,4-oxadiazole-5-carbonyl]amino]-1-[3-trifluoromethylphenyl]thiourea |
NA |
192000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
4-(3-{[Amino(phenylimino)methyl]sulfanyl}-2,5-dioxo-1-pyrrolidinyl)benzoic acid |
NA |
3466000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
6-Phenyl-5,6,6a,7,8,9,10,10a-octahydro-7,10-methanophenanthridine-2-carboxamide |
NA |
118400 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT1 |
Surfactin |
NA |
600000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT1 |
1-[(4-Ethoxyphenyl)methyl]-5-[(2-hydroxynaphthalen-1-yl)methyl]-6-phenyl-2-sulfanylidenepyrimidin-4-one |
NA |
120000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT1 |
(S)-Methyl 2-((S)-2-((S)-2-acetamidopropanamido)-6-pivalamidohexanamido)propanoate |
NA |
223000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
N-[(3-pyridin-3-yl-1H-1,2,4-triazol-5-yl)methyl]pyrazine-2-carboxamide |
NA |
1470000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT1 |
N-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide |
NA |
238000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
2,4-dioxo-N-(4-(pyridin-3-yloxy)phenyl)-1,2,3,4-tetrahydroquinazoline-6-sulfonamide |
NA |
314000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
2,4-dioxo-N-[3-(2-pyridin-4-ylethyl)phenyl]-1H-quinazoline-6-sulfonamide |
NA |
424000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
(S)-Methyl 2-((S)-2-((S)-2-acetamidopropanamido)-6-(2-bromoacetamido)hexanamido)propanoate |
NA |
1767000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
(S)-2-((S)-6-Acetamido-2-((S)-2-acetamidopropanamido)hexanamido)propanoic acid |
NA |
122000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
(S)-Methyl 2-((S)-6-acetamido-2-((S)-2-acetamidopropanamido)hexanamido)propanoate |
NA |
268000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
3-(3,5-Difluorophenyl)-1-benzofuran-4,6-diol |
NA |
274000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT1 |
3-(4-Fluorophenyl)benzofuran-4,6-diol |
NA |
192000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT1 |
Ac-Lys(Ac)-Asu(NH2)(NH2)-Lys(Ac)-NH2 |
NA |
290000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
|
NA |
120000|123000|123300|131000|245000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT1 |
2-(3-Cyclohexylmethoxyphenylamino)Benzamide |
NA |
210000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
2-(3-Isobutoxyphenylamino)Benzamide |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |