| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| SIRT1 |
4-[(6-bromo-2-hydroxynaphthalen-1-yl)methyl]-3-(4-methylphenyl)-2H-1,2-oxazol-5-one |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT1 |
benzyl N-[(2S)-8-amino-1-anilino-1,8-dioxooctan-2-yl]carbamate |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT1 |
1-[(4-Ethoxyphenyl)methyl]-5-[(2-methoxynaphthalen-1-yl)methyl]-6-phenyl-2-sulfanylidenepyrimidin-4-one |
NA |
120000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT1 |
5-[(2-Hydroxynaphthalen-1-yl)methyl]-6-phenyl-1-[(4-propoxyphenyl)methyl]-2-sulfanylidenepyrimidin-4-one |
NA |
120000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT1 |
|
NA |
3700000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT1 |
5-[4-(Furan-2-amido)benzamido]-2-hydroxybenzoic acid |
NA |
783000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT1 |
Niacinamide |
NA |
118000|149000|250000|520000 |
NA |
NA |
NA |
NA |
BindingDB|PubChem |
| SIRT1 |
3-(1H-1,2,3-triazol-4-yl)pyridine |
NA |
146000|261000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
(4R,5R)-5-(hydroxymethyl)-2,2-dimethyl-N-phenylmethoxy-1,3-dioxolane-4-carboxamide |
NA |
502800 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
[[(2R,3S,4R,5R)-4-amino-5-(3-carbamoylpyridin-1-ium-1-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate |
NA |
151000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
[(6aR,10aR)-7-methyl-4-propan-2-yl-6,6a,8,10a-tetrahydroindolo[4,3-fg]quinolin-9-yl]methyl 4-methoxycyclohexane-1-carboxylate |
NA |
102000|177000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
benzyl 2-[(2R)-3-bis(phenylmethoxy)phosphoryloxy-2-hydroxypropyl]sulfanylacetate |
NA |
143000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
[(2R,3R)-3-acetyloxy-1-bis(phenylmethoxy)phosphoryloxy-4-oxo-4-(phenylmethoxyamino)butan-2-yl] acetate |
NA |
207000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
1-(6-Chloro-2,2-dimethyl-3,4-dihydrochromen-4-yl)-3-(4-nitrophenyl)thiourea |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
[[(2R,3S,4R,5R)-5-(6-amino-8-phenylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate |
NA |
123000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
2-Methyl-8-(4-methylsulfonylphenyl)-1,3,4,5-tetrahydropyrido[4,3-b]indole |
NA |
250000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
5-(2-Methyl-1,3,4,5-tetrahydropyrido[4,3-b]indol-8-yl)pyrimidin-2-amine |
NA |
250000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
3-[[(5S)-6-anilino-6-oxo-5-(phenylmethoxycarbonylamino)hexyl]amino]-3-sulfanylidenepropanoic acid |
NA |
256000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
phenyl N-[1-anilino-6-(ethanethioylamino)-1-oxohexan-2-yl]carbamate |
NA |
105000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
2-({[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]carbonyl}amino)-5-hydroxybenzoic acid |
NA |
333000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |