| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| SIRT2 |
N-[4-[[3-[[2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetyl]amino]phenyl]methoxy]phenyl]thiophene-2-carboxamide |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
N-[4-[[3-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]-3-[[(1R,2R)-2-hydroxycyclohexyl]amino]propanamide |
NA |
301995.17 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
N-[4-[[3-[(2-naphthalen-1-yloxyacetyl)amino]phenyl]methoxy]phenyl]thiophene-2-carboxamide |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
benzyl N-[2-[4-[[3-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]anilino]-2-oxoethyl]carbamate |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
N-[3-[[3-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]furan-2-carboxamide |
NA |
122600|123027 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
N-[3-[[3-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]thiophene-2-carboxamide |
NA |
127700|128825 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
N-[4-[[3-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]-2-ethoxyacetamide |
NA |
109500|109648 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
N-[4-[[3-[[2-(1H-1,2,4-triazol-5-ylsulfanyl)acetyl]amino]phenyl]methoxy]phenyl]thiophene-2-carboxamide |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
N-[3-[[3-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]oxane-4-carboxamide |
NA |
168800|169824 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
N-[3-[[3-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]pyridine-2-carboxamide |
NA |
301995.17 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
1-methyl-N-[4-[[3-[[2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetyl]amino]phenyl]methoxy]phenyl]pyrazole-4-carboxamide |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
tert-butyl N-[4-[4-[[3-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]anilino]-4-oxobutyl]carbamate |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
2-acetamido-N-[4-[[3-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]acetamide |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
N-[4-[[3-[[2-[(2-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetyl]amino]phenyl]methoxy]phenyl]thiophene-2-carboxamide |
NA |
269153|269700|269153.48 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
N-[4-[[3-[[2-(3-methoxyphenyl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]thiophene-2-carboxamide |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
N-[3-[[3-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]pyrrolidine-2-carboxamide |
NA |
141254|141600|141253.75 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
tert-butyl N-[4-[[3-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]carbamate |
NA |
100200 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-[4-(octylamino)-4-oxobutyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoic acid |
NA |
237000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
tert-butyl N-[3-[4-[[3-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]anilino]-3-oxopropyl]carbamate |
NA |
300000|301995 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
[[(2R,3S,4S,5R)-4-amino-5-(3-carbamoylpyridin-1-ium-1-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate |
NA |
153400 |
NA |
NA |
NA |
NA |
BindingDB |