| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| SIRT2 |
1,3-dimethyl-2,4-dioxo-N-[4-(pyridin-4-ylmethyl)phenyl]-1,2,3,4-tetrahydroquinazoline-6-sulfonamide |
NA |
242000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-[(4-phenylphenyl)methyl]-1,3-thiazol-2-yl]acetamide |
NA |
164500 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
N-[5-[(4-bromophenyl)methyl]-1,3,4-thiadiazol-2-yl]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide |
NA |
167700 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
2-(3-hydroxyphenyl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide |
NA |
143000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
2-(3,5-dimethylphenyl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide |
NA |
207000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
1-[2-[[5-(Naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]amino]-2-oxoethyl]pyridin-1-ium-3-carboxamide;chloride |
NA |
289000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide |
NA |
15500000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
(2S)-6-acetamido-2-[[(2S)-6-[6-(1,3-benzothiazol-2-ylsulfanyl)hexanoylamino]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
(1R,3R,5R)-7-benzoyl-6-methoxy-4,4-dimethyl-1,5-bis(3-methylbut-2-enyl)-8,9-dioxobicyclo[3.3.1]non-6-ene-3-carboxylic acid |
NA |
150000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide |
NA |
12500000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
Mdl-800 |
NA |
100400 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
N,N''-bis(4-hydroxybenzylidene)naphthalene1,4diamine |
NA |
137400 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide |
NA |
127200 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione |
NA |
243600 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
1-methyl-N-[4-[[3-[(2-naphthalen-1-yloxyacetyl)amino]phenyl]methoxy]phenyl]pyrazole-4-carboxamide |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
N-[4-[[3-[[2-(3,5-dimethylphenoxy)acetyl]amino]phenyl]methoxy]phenyl]thiophene-2-carboxamide |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
N-[4-[[3-[[2-[(1-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetyl]amino]phenyl]methoxy]phenyl]thiophene-2-carboxamide |
NA |
141254|141600|141253.75 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
N-[4-[[3-[[2-(3-methylphenyl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]thiophene-2-carboxamide |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
N-[4-[[3-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]-4-[[(1R,2R)-2-hydroxycyclohexyl]amino]butanamide |
NA |
173780|175000|173780.08 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
3-amino-N-[4-[[3-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]propanamide |
NA |
300000|301995 |
NA |
NA |
NA |
NA |
BindingDB|TTD |