| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| SIRT2 |
(2S)-2-[[(2S)-2-acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-6-amino-N-[(2S)-6-(ethanethioylamino)-1-[[(10S,13S)-10-(2-methylsulfanylethyl)-9,12-dioxo-2-oxa-8,11-diazabicyclo[13.2.2]nonadeca-1(17),15,18-trien-13-yl]amino]-1-oxohexan-2-yl]hexanamide |
NA |
115100 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
|
NA |
137400 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
N,N''-bis(3-hydroxybenzylidene)naphthalene1,4diamine |
NA |
195900 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
7-fluoro-N-[2-[2-[2-[[7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carbonyl]amino]ethoxy]ethoxy]ethyl]-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxamide |
NA|111000 |
383000|NA |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
7-fluoro-N-[2-[2-[2-[2-[[7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carbonyl]amino]ethoxy]ethoxy]ethoxy]ethyl]-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxamide |
NA |
316000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
N-[6-[[2-(2-bicyclo[2.2.1]heptanyl)-2-oxoethyl]amino]hexyl]-3-oxo-1,2-dihydroindene-1-carboxamide |
NA|272000 |
938000|NA |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-N-[[4-[[3-(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)propanoylamino]methyl]phenyl]methyl]-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxamide |
NA |
193000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
7-fluoro-N-[[4-[[[7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carbonyl]amino]methyl]phenyl]methyl]-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxamide |
NA |
186000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-N-[[4-[[[2-(3,4,5-trimethoxyphenyl)acetyl]amino]methyl]phenyl]methyl]-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxamide |
NA|286000 |
985000|NA |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
7-fluoro-N-[3-[[7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carbonyl]amino]propyl]-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxamide |
NA |
303000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
3-pyridin-3-yl-N-[3-[[2-(3,4,5-trimethoxyphenyl)acetyl]amino]propyl]benzamide |
NA |
299000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-N-[2-[2-[2-[3-(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)propanoylamino]ethoxy]ethoxy]ethyl]-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxamide |
NA |
186000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-N-[6-[3-(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)propanoylamino]hexyl]-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxamide |
NA |
107000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
2-benzoyl-1H-benzo[f]chromen-3(2H)-one |
NA |
178700 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
[[(2R,3S,4R,5S)-4-amino-5-(3-carbamoylpyridin-1-ium-1-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate |
NA |
118000 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
SIRT5 inhibitor 8 |
NA |
135600 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
SIRT5 inhibitor 9 |
NA |
110700 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
Srt-1460 |
NA |
NA |
NA |
300000 |
NA |
NA |
TTD |
| SIRT2 |
(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)methyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthamide |
NA |
NA |
NA |
300000 |
NA |
NA |
TTD |
| SIRT2 |
2-(3-(4-tert-butylphenyl)-1,2,4-oxadiazole-5-carbonyl)-N-(4-(trifluoromethyl)phenyl)hydrazinecarbothioamide |
NA |
109000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |