| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| SIRT2 |
3-[[3-(Naphthalen-1-yl)1,2,4-oxadiazole-5-carbonyl]amino]-1-[3-trifluoromethylphenyl]thiourea |
NA |
113000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
3-[[3-(Naphthalen-1-yl)1,2,4-oxadiazole-5-carbonyl]amino]-1-[3-trifluoromethylphenyl]urea |
NA |
257000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
3-[[3-(tert-Butoxycarbonylamino-phenyl)-1,2,4-oxadiazole-5-carbonyl]amino]-1-(4-(trifluoromethyl)phenyl)thiourea |
NA |
129000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
2-((4-(3-(4-(2-Hydroxybenzylideneamino)phenoxy)propoxy)phenylimino)methyl)phenol |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
4-(2-(4-(4-chlorophenyl)-5-mercapto-4H-1,2,4-triazol-3-yl)ethyl)phenol |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
4-((4-(4-(3,4-Dihydroxybenzylideneamino)benzyl)phenylimino)methyl)benzene-1,2-diol |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
2-(2-Oxo-2-(4-(2-(trifluoromethyl)quinolin-4-yl)piperazin-1-yl)ethylthio)acetic acid |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
3-(3-(4-(Phenoxymethyl)phenyl)ureido)benzoic acid |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
5-(4-Benzamido-2-methoxy-5-methylphenylamino)-5-oxo-3-phenylpentanoic acid |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
4,4'-Bis[(2-hydroxyethyl)methylamino]benzophenone |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
5-(9-oxo-9H-xanthen-2-yloxy)pentanoic acid |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
6-(2-Hydroxy-ethylsulfanyl)-2-(2-pyridin-2-yl-ethyl)-benzo[de]isoquinoline-1,3-dione |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
2-fluoro-N-(quinolin-2-ylmethyl)aniline |
NA |
164500 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT2 |
4-(3-{[Amino(phenylimino)methyl]sulfanyl}-2,5-dioxo-1-pyrrolidinyl)benzoic acid |
NA |
1744000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide |
NA |
502800 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
(S)-N-(1-(2-(1H-indol-3-yl)ethylamino)-1-oxopropan-2-yl)cinnamamide |
NA |
109000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
N-(3-(2-ethylhexyloxy)propyl)-4,4-bis(4-hydroxyphenyl)pentanamide |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
3-[(2-Cyano-ethyl)-(4-{4-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-thiazol-2-yl]-piperidin-1-ylmethyl}-phenyl)-amino]-propionitrile |
NA |
136000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| SIRT2 |
2-(4-((2-(Tert-butoxycarbonyl)-3-phenylpropanoyloxy)methyl)phenyl)acetic acid |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT2 |
2-((4-(4-(4-(2-Hydroxybenzylideneamino)phenoxy)butoxy)phenylimino)methyl)phenol |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |