| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| SIRT3 |
5-[5-[(4-Methyl-3-nitrobenzoyl)amino]naphthalen-1-yl]oxypyridine-3-carboxamide |
NA |
232000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
5-((1-benzyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione |
NA |
116300 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
3-[(2-Methoxynaphthalen-1-yl)methyl]-7-[(4-methoxyphenyl)methylamino]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one |
NA |
177400 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
5-[[3-[(4-Phenylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
5-[[3-[(4-Phenylmethoxybenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
N-[3-[(5-carbamoylpyridin-3-yl)oxymethyl]phenyl]-6-thiophen-2-ylpyridine-3-carboxamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
4-[[3-[(5-Carbamoylpyridin-3-yl)oxymethyl]phenyl]carbamoyl]benzoic acid |
NA |
106000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
5-[[3-(Adamantane-1-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-(naphthalen-2-ylmethyl)-1,3-thiazol-2-yl]acetamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
(2S)-6-acetamido-2-[[(2S)-6-[6-(1,3-benzothiazol-2-ylsulfanyl)hexanoylamino]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamide |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
N-[4-[[3-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]thiophene-2-carboxamide |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-[4-(decylamino)-4-oxobutyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoic acid |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-[4-(octylamino)-4-oxobutyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoic acid |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
SIRT2 inhibitor AF10 |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
benzyl N-[(2S)-1-anilino-6-(dodecylcarbamothioylamino)-1-oxohexan-2-yl]carbamate |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
SIRT5 inhibitor 9 |
NA |
500200 |
NA |
NA |
NA |
NA |
BindingDB |
| SIRT3 |
Srt-1460 |
NA |
NA |
NA |
300000 |
NA |
NA |
TTD |
| SIRT3 |
(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)methyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthamide |
NA |
NA |
NA |
300000 |
NA |
NA |
TTD |
| SIRT3 |
ethyl 3-[[(5S)-6-anilino-6-oxo-5-(phenylmethoxycarbonylamino)hexyl]amino]-3-oxopropanoate |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
Resveratrol |
NA |
NA |
NA |
300000 |
NA |
NA |
PubChem|TTD |