| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| SIRT3 |
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
NA |
128000 |
NA |
NA |
NA |
NA |
ChEMBL|PubChem |
| SIRT3 |
Ac-Lys(Ac)-Asu(NH2)(NH2)-Lys(Ac)-NH2 |
NA |
213500 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
2-((3-Phenethoxyphenyl)Amino)Benzamide |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
tert-butyl N-[4-[(3-cyanophenyl)carbamoylamino]-2,2-dimethyl-3,4-dihydrochromen-6-yl]carbamate |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
2-{3-(3-Fluorophenethyloxy)phenylamino}benzamide |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
(s)-8-Bromo-6-chloro-2-pentylchroman-4-one |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
8-[4-methyl-3-[(5Z)-5-[(Z)-[5-[[2-methyl-5-[(4,6,8-trisulfo-2H-naphthalen-1-ylidene)carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]iminocyclohexa-1,3-diene-1-carbonyl]iminocyclohexa-1,4-diene-1-carbonyl]imino-7H-naphthalene-1,3,5-trisulfonic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
4-[(6-Bromo-2-hydroxynaphthalen-1-yl)methyl]-5-(4-methylphenyl)-1,2-dihydropyrazol-3-one |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
4-[(2-Hydroxy-3-methoxynaphthalen-1-yl)methyl]-5-(4-methylphenyl)-1,2-dihydropyrazol-3-one |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
4-[(2-Chloro-6-hydroxyquinolin-5-yl)methyl]-5-(4-propan-2-ylphenyl)-1,2-dihydropyrazol-3-one |
NA |
122000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
4-[(6-bromo-2-hydroxynaphthalen-1-yl)methyl]-3-(4-methylphenyl)-2H-1,2-oxazol-5-one |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT3 |
Niacinamide |
NA |
377000 |
NA |
NA |
NA |
NA |
PubChem |
| SIRT3 |
2-Anilinobenzamide |
NA |
235000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT5 |
5-({3-[4-(Morpholin-4-yl)benzamido]phenyl}methoxy)pyridine-3-carboxamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT5 |
Ac-2Nal-Lys(TAc)(TAc)-Dap(Ac)(Ac)-NH2 |
NA |
2000000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT5 |
5-[[3-(Pyridine-4-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT5 |
5-[[3-(Pyridine-3-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT5 |
Thiomyristoyl |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT5 |
(2S,5S,8S)-2-(1-benzothiophen-3-ylmethyl)-5-[4-(ethanethioylamino)butyl]-3,6,14,21-tetraoxo-1,4,7,13-tetrazacyclohenicosane-8-carboxamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| SIRT5 |
(2S,5S,8S)-2-butyl-5-[4-(ethanethioylamino)butyl]-3,6,13,20-tetraoxo-1,4,7,12-tetrazacycloicosane-8-carboxamide |
NA |
400000 |
NA |
NA |
NA |
NA |
TTD |