| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| SIRT6 |
Niacinamide |
NA |
184000|200000|120000|153000|150000 |
NA |
NA |
NA |
NA |
PubChem |
| SLC10A1 |
Bosentan |
NA |
30000000 |
NA |
NA |
NA |
NA |
BindingDB|PubChem|TTD |
| SLC10A1 |
Macitentan |
NA |
10000000 |
NA |
NA |
NA |
NA |
BindingDB|PubChem|TTD |
| SLC10A1 |
2-[[2-(3-Hexyl-2-oxochromen-7-yl)oxyacetyl]amino]-4-methylsulfanylbutanoic acid |
NA |
238000 |
NA |
NA |
NA |
NA |
BindingDB |
| SLC10A1 |
Betulin Diacetate |
NA |
199000 |
NA |
NA |
NA |
NA |
BindingDB |
| SLC10A1 |
2-[[2-(3-Hexyl-4-methyl-2-oxochromen-7-yl)oxyacetyl]amino]-3-phenylpropanoic acid |
NA |
145000 |
NA |
NA |
NA |
NA |
BindingDB |
| SLC10A1 |
1-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone |
NA |
264000 |
NA |
NA |
NA |
NA |
PubChem |
| SLC10A1 |
2-[[2-(3-Benzyl-4-methyl-2-oxochromen-7-yl)oxyacetyl]amino]-3-benzylsulfanylpropanoic acid |
NA |
150000 |
NA |
NA |
NA |
NA |
BindingDB |
| SLC10A1 |
Ketoconazole |
NA |
264000 |
NA |
NA |
NA |
NA |
BindingDB |
| SLC10A1 |
3-Benzylsulfanyl-2-[[2-[(4-methyl-6-oxo-7,8,9,10-tetrahydrobenzo[c]chromen-3-yl)oxy]acetyl]amino]propanoic acid |
NA |
123000 |
NA |
NA |
NA |
NA |
BindingDB |
| SLC10A1 |
Betulin |
NA |
109000 |
NA |
NA |
NA |
NA |
BindingDB|PubChem |
| SLC10A2 |
2-[[(4R)-4-[(2S,12R,18R,19S)-12,19-dihydroxy-6-[(3-hydroxyphenyl)methyl]-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4,7-dien-17-yl]pentanoyl]amino]acetic acid |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SLC10A2 |
2-[(4R)-4-[(2S,18R)-6-[(3-{[(2S)-2-(6-methoxynaphthalen-2-yl)propanoyl]oxy}phenyl)methyl]-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4,7-dien-17-yl]pentanamido]acetic acid |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SLC10A2 |
2-[(4R)-4-[(2S,12R,18R)-12-hydroxy-6-[(3-{[(2S)-2-(6-methoxynaphthalen-2-yl)propanoyl]oxy}phenyl)methyl]-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4,7-dien-17-yl]pentanamido]acetic acid |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SLC10A2 |
2-[[(4R)-4-[(2S,18R)-6-(2-hydroxyethyl)-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4,7-dien-17-yl]pentanoyl]amino]acetic acid |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| SLC10A2 |
4-((4S)-4-carboxylato-4-((4R)-4-((3R,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)butanamido)benzoate |
108000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| SLC10A2 |
3-(((4S)-4-carboxylato-4-((4R)-4-((3R,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)butanamido)methyl)benzoate |
126000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| SLC10A2 |
Sulfobromophthalein Sodium |
144000 |
NA |
NA |
NA |
NA |
NA |
PubChem |
| SLC12A5 |
1-(4-Methoxyphenyl)-4-[(3-methylphenyl)imino]-1,3-diazaspiro[4.5]decane-2-thione |
NA |
NA |
NA |
771000 |
NA |
NA |
BindingDB |
| SLC12A5 |
N-[2-(2-fluorophenyl)-1,3-benzoxazol-5-yl]furan-2-carboxamide |
NA |
NA |
NA |
827000 |
NA |
NA |
BindingDB |