| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| SRC |
3-(2-{(S)-1-[(S)-1-((S)-(S)-1-Carbamoyl-2-methyl-butylcarbamoyl)-3-carboxy-propylcarbamoyl]-3-carboxy-propylcarbamoyl}-ethyl)-benzoic acid |
NA |
250000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
{(S)-2-[4-(Benzyloxy-hydroxy-phosphoryloxy)-phenyl]-1-[2-(4-methoxy-phenyl)-5-(naphthalen-1-ylcarbamoylmethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester |
NA |
133000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
[(S)-1-[5-(3-Cyclohexyl-propyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylcarbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester |
NA |
164000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
[(S)-2-[4-(Benzyloxy-hydroxy-phosphoryloxy)-phenyl]-1-(2-(4-methoxy-phenyl)-5-{[(naphthalen-1-ylmethyl)-carbamoyl]-methyl}-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester |
NA |
128000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
{(S)-2-[4-(Benzyloxy-hydroxy-phosphoryloxy)-phenyl]-1-[2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester |
NA |
873000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
[(S)-1-[4-(3-Cyclohexyl-propyl)-5-oxo-[1,4]thiazepan-6-ylcarbamoyl]-2-(4-phosphonooxy-phenyl)-ethyl]-carbamic acid tert-butyl ester |
NA |
115000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
[(R)-1-[5-(3-Cyclohexyl-propyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylcarbamoyl]-2-(4-phosphonooxy-phenyl)-ethyl]-carbamic acid tert-butyl ester |
NA |
422000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
Benzyl [4-[3-[[2-(4-methoxyphenyl)-5-[2-(naphthalen-1-ylmethylamino)-2-oxoethyl]-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl]amino]-3-oxopropyl]phenyl] hydrogen phosphate |
NA |
339000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
Trifluoro-methanesulfonic acid 4-{2-[1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-phosphono-phenyl ester |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
{4-[2-Acetylamino-2-(3-carbamoyl-4-cyclohexylmethoxy-benzylcarbamoyl)-ethyl]-2-phosphono-phenoxy}-acetic acid |
NA |
378000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
[5-{2-[1-(3-Carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-(tetrazol-1-ylmethoxy)-phenyl]-phosphonic acid |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
(4-{2-Acetylamino-2-[(S)-1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-ethylcarbamoyl]-ethyl}-phenoxy)-acetic acid |
NA |
370000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
{4-[2-Acetylamino-2-(3-carbamoyl-4-cyclohexylmethoxy-phenylcarbamoyl)-ethyl]-2-phosphono-phenoxy}-acetic acid |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
(5-{2-[1-(3-Carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-hydroxy-phenyl)-phosphonic acid |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
[4-[(2S)-2-acetamido-3-[[(1S)-1-[3-(cyclohexylmethyl)phenyl]propyl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate |
NA |
306000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
[4-[(2S)-2-acetamido-3-[[(1S)-2-(1H-indol-3-yl)-1-[3-(naphthalen-1-ylmethyl)-1,2,4-oxadiazol-5-yl]ethyl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate |
NA |
279000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
(S)-4-[(S)-2-Acetylamino-3-(4-phosphonooxy-phenyl)-propionylamino]-4-(4-isobutyl-thiazol-2-yl)-butyric acid |
NA |
218000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
[4-[(2S)-2-acetamido-3-[[3-(cyclohexylmethyl)-1,2,4-oxadiazol-5-yl]methylamino]-3-oxopropyl]phenyl] dihydrogen phosphate |
NA |
896000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
(S)-4-[(S)-2-Acetylamino-3-(4-phosphonooxy-phenyl)-propionylamino]-4-(3-isobutyl-[1,2,4]oxadiazol-5-yl)-butyric acid |
NA |
166000 |
NA |
NA |
NA |
NA |
TTD |
| SRC |
[4-[(2S)-2-acetamido-3-[[(1S)-4-amino-1-[3-(cyclohexylmethyl)-1,2,4-oxadiazol-5-yl]-4-oxobutyl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate |
NA |
2780000 |
NA |
NA |
NA |
NA |
TTD |