| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TGFBR1 |
4-(2-Aminophenyl)-1,2-dihydro-1,2-dimethyl-5-(quinoxalin-7-yl)pyrazol-3-one |
952000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TGFBR1 |
4-(3-isopropylphenyl)-1,2-dimethyl-5-(quinoxalin-6-yl)-1H-pyrazol-3(2H)-one |
2800000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TGFBR1 |
1-(3-(1,2-dimethyl-3-oxo-5-(quinoxalin-6-yl)-2,3-dihydro-1H-pyrazol-4-yl)phenyl)-3-methylurea |
2800000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TGFBR1 |
N-(3-(1,2-dimethyl-3-oxo-5-(quinoxalin-6-yl)-2,3-dihydro-1H-pyrazol-4-yl)phenyl)ethanesulfonamide |
2800000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TGM2 |
Dihydroisoxazole, 1f |
110000|310000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| TGM2 |
2-[(3-Bromo-4,5-dihydroisoxazol-5-ylmethyl)carbamoyl]-2,3-dihydroindole-1-carboxylic acid benzyl ester |
138000 |
NA |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TGM2 |
3-[2-[(E)-2-(3-nitrophenyl)ethenyl]oxiran-2-yl]pyridine |
NA |
151000 |
NA |
NA |
NA |
NA |
TTD |
| TGM2 |
[(1S,2S)-2-(3-nitrophenyl)cyclopropyl]-pyridin-4-ylmethanone |
NA |
147000 |
NA |
NA |
NA |
NA |
TTD |
| TGM2 |
3-(Benzotriazole-1-carbonyl)-6-nitrochromen-2-one |
NA |
145000 |
NA |
NA |
NA |
NA |
TTD |
| TGM2 |
(E)-3-(3,4-dihydroxyphenyl)-1-pyridin-3-ylprop-2-en-1-one |
NA |
1001000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TGM2 |
N-[4-[4-(naphthalene-1-carbonyl)piperazin-1-yl]-4-oxobutyl]prop-2-enamide |
134000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| TGM2 |
N-[5-[4-(naphthalene-1-carbonyl)piperazin-1-yl]-5-oxopentyl]prop-2-enamide |
141900 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| TGM2 |
N-[6-[4-(naphthalene-1-carbonyl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide |
109300 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| TGM2 |
N-[(5S)-5-(methanesulfonamido)-6-[4-(naphthalene-1-carbonyl)piperazin-1-yl]-6-oxohexyl]prop-2-enamide |
253000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| TGM2 |
N-[2-[4-(adamantane-1-carbonyl)piperazin-1-yl]-2-oxoethyl]-2-oxopropanamide |
154000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| TGM2 |
1-{4-[(2,3-Dioxo-2,3-dihydro-1H-indol-1-YL)methyl]-2,5-dimethylbenzyl}-1H-indole-2,3-dione |
NA |
250000 |
NA |
NA |
NA |
NA |
TTD |
| TGM2 |
(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-4-carbamoyl-2-[(2S)-pyrrolidin-2-ylformamido]butanoyl]pyrrolidin-2-yl]formamido}-3-(2-oxoacetamido)propanamido]-4-methylpentanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoic acid |
300000 |
NA |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TGM2 |
(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-4-carbamoyl-2-[(2S)-pyrrolidin-2-ylformamido]butanoyl]pyrrolidin-2-yl]formamido}-5-(2-oxoacetamido)pentanamido]-4-methylpentanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoic acid |
200000 |
NA |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TGM2 |
Dihydroisoxazole, 1a |
740000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| TGM2 |
Dihydroisoxazole, 1b |
420000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |