| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TK1 |
[(2S,3S,4R,5R)-3-(aminomethyl)-4-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate |
280000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| TK1 |
1-(4,5-Dihydroxy-tetrahydro-furan-2-yl)-5-methylsulfanyl-1H-pyrimidin-2-one |
160000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| TK1 |
N-[(Z)-4-(5-methyl-2,4-dioxopyrimidin-1-yl)but-2-enyl]-9H-xanthene-9-carboxamide |
NA |
131000 |
NA |
NA |
NA |
NA |
BindingDB |
| TK1 |
1-[4-(4-Benzyl-piperazin-1-yl)-but-2-enyl]-5-methyl-1H-pyrimidine-2,4-dione |
NA |
180000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TK1 |
2-(4-Chloro-phenyl)-N-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-but-2-enyl]-acetamide |
NA |
198000 |
NA |
NA |
NA |
NA |
BindingDB |
| TK1 |
5-Methyl-1-[4-(4-methyl-piperazin-1-yl)-but-2-enyl]-1H-pyrimidine-2,4-dione |
NA |
491000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TK1 |
N-[4-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-but-2-enyl]-2,2-diphenyl-acetamide |
NA |
115000 |
NA |
NA |
NA |
NA |
BindingDB |
| TK1 |
2-Biphenyl-4-yl-N-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-but-2-enyl]-acetamide |
NA |
119000 |
NA |
NA |
NA |
NA |
BindingDB |
| TK1 |
3-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-(3-hydroxyphenyl)furo[2,3-d]pyrimidin-2(3H)-one |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TK1 |
6-[3-(2-fluoroethoxy)phenyl]-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]furo[2,3-d]pyrimidin-2-one |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TK1 |
3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(3-methoxyphenyl)furo[2,3-d]pyrimidin-2-one |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TK1 |
6-(2-fluorophenyl)-3-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]furo[2,3-d]pyrimidin-2-one |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TK1 |
1-(2''-O-octanoyl-beta-D-arabinofuranosyl)thymine |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TK1 |
[(2R,3S,4R,5R)-4-hydroxy-5-(hydroxymethyl)-2-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] dodecanoate |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TK1 |
N3-octyl-1-(beta-D-arabinofuranosyl)thymine |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TK1 |
1-(4-Hydroxy-5-hydroxymethyl-3-octyloxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TK1 |
1-[2''-O-(4-aminobutanoyl)-beta-D-arabinofuranosyl]-5(E)-(2-bromovinyl)uracil |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TK1 |
1-[2''-O-(6-aminohexanoyl)-beta-D-arabinofuranosyl]-5(E)-(2-bromovinyl)uracil |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TK1 |
1-(2''-O-octyl-beta-D-arabinofuranosyl)cytosine |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TK1 |
2'',3''-Dideoxy-3''-(trichloromethyldithio)thymidine |
NA |
365000 |
NA |
NA |
NA |
NA |
BindingDB |