| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TK1 |
3-(4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-(4-methoxy-phenyl)-3H-furo[2,3-d]pyrimidin-2-one |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TK1 |
1-[(2R,4S,5R)-5-(hydroxymethyl)-4-(methyldisulfanyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione |
NA |
333000 |
NA |
NA |
NA |
NA |
BindingDB |
| TK1 |
1-(4-Aminomethyl-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione |
220000 |
NA |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TK1 |
1-(4-Aminomethyl-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione |
110000 |
NA |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TK1 |
[(2S,3S,4R,5R)-3-(aminomethyl)-4-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate |
280000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| TK1 |
Sorivudine |
NA |
500000 |
NA |
NA |
NA |
NA |
PubChem|TTD |
| TK1 |
Thymidine |
NA |
500000 |
NA |
NA |
NA |
NA |
PubChem |
| TK1 |
Cytarabine |
NA |
1000000 |
NA |
NA |
NA |
NA |
PubChem|TTD |
| TK1 |
Octanoic acid 2-[5-((E)-2-bromo-vinyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TK1 |
Methoxy-acetic acid 2-[5-((E)-2-bromo-vinyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TK1 |
Spongothymidine |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TK1 |
2',3'-Didehydro-2',3'-dideoxyuridine |
445000 |
NA |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TK1 |
5'-O-benzoyl-3'-deoxythymidine |
580000|425000 |
NA |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TK1 |
4-Amino-1-(4-hydroxy-5-hydroxymethyl-3-octyloxy-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TK1 |
1-(4,5-Bis-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione |
420000 |
NA |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TK2 |
N-methyl-4-[1,1-(diphenyl)-1-(Z)-[4-(thymin-1-yl)but-2-enoxy]methyl]pyridinium iodide |
NA |
114000 |
NA |
NA |
NA |
NA |
BindingDB |
| TK2 |
1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-phenylmethoxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione |
NA |
801000 |
NA |
NA |
NA |
NA |
BindingDB |
| TK2 |
1-(2''-O-octanoyl-beta-D-arabinofuranosyl)thymine |
NA |
120000 |
NA |
NA |
NA |
NA |
BindingDB |
| TK2 |
1-(4-Hydroxy-5-hydroxymethyl-3-octyloxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione |
NA |
120000 |
NA |
NA |
NA |
NA |
BindingDB |
| TK2 |
1-(2''-N-nonylcarboxamido-2''-deoxy-beta-D-arabinofuranosyl)thymine |
NA |
480000 |
NA |
NA |
NA |
NA |
BindingDB |