| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TK2 |
1-[2''-O-(4-aminobutanoyl)-beta-D-arabinofuranosyl]-5(E)-(2-bromovinyl)uracil |
NA |
187000 |
NA |
NA |
NA |
NA |
BindingDB |
| TK2 |
1-(3-Benzyloxy-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione |
NA |
801000 |
NA |
NA |
NA |
NA |
BindingDB |
| TK2 |
Cytarabine |
NA |
1000000 |
NA |
NA |
NA |
NA |
PubChem |
| TK2 |
Methoxy-acetic acid 2-[5-((E)-2-bromo-vinyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester |
NA |
402000 |
NA |
NA |
NA |
NA |
BindingDB |
| TK2 |
Spongothymidine |
NA |
285000 |
NA |
NA |
NA |
NA |
BindingDB |
| TKT |
Thiamine |
NA |
NA |
6800000 |
NA |
NA |
NA |
BindingDB|PubChem |
| TKT |
N-[(2-amino-6-methylpyridin-3-yl)methyl]-N-[(Z)-2-[[(Z)-1-[(2-amino-6-methylpyridin-3-yl)methyl-formylamino]-4-hydroxybut-1-en-2-yl]disulfanyl]-4-hydroxybut-1-enyl]formamide |
NA |
NA |
NA |
101870 |
NA |
NA |
BindingDB|TTD |
| TLR4 |
MD2-Tlr4-IN-1 |
NA |
NA |
146000 |
NA |
NA |
NA |
BindingDB |
| TLR4 |
2-[methyl-[(4-oxo-5-phenyl-3H-thieno[2,3-d]pyrimidin-2-yl)methyl]amino]-N-(4-morpholin-4-ylphenyl)acetamide |
NA |
167500 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TLR4 |
2-[(E)-[4-[(E)-(diaminomethylidenehydrazinylidene)methyl]-2,3-dimethoxyphenyl]methylideneamino]guanidine |
NA |
175000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TLR4 |
2-[(E)-[4-[(E)-(diaminomethylidenehydrazinylidene)methyl]-2,3-di(tetradecoxy)phenyl]methylideneamino]guanidine |
NA |
190000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TLR4 |
1-[[1-[(2-Chlorophenyl)methyl]-3,5-dimethylpyrazol-4-yl]methyl-methylamino]-3-(4-ethoxyphenoxy)propan-2-ol |
NA |
110500|315600|318400 |
NA |
NA |
NA |
NA |
BindingDB |
| TLR4 |
N,N-(4-Xylylidene)bisaminoguanidine |
NA |
164000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TLR7 |
4-[(4-Amino-2-butyl-7-methoxycarbonylimidazo[4,5-c]quinolin-1-yl)methyl]benzoic acid |
NA |
NA |
NA |
190000 |
NA |
NA |
TTD |
| TLR7 |
CID 153282971 |
NA |
NA |
NA |
376000 |
NA |
NA |
GtoPDB |
| TLR7 |
8-Methyl-1-(2-methylpropyl)chromeno[3,4-d]imidazol-4-one |
NA |
NA |
NA |
535000 |
NA |
NA |
TTD |
| TLR7 |
7-Methoxy-1-(2-methylpropyl)chromeno[3,4-d]imidazol-4-one |
NA |
NA |
NA |
279000 |
NA |
NA |
TTD |
| TLR7 |
7-Hydroxy-1-(2-methylpropyl)chromeno[3,4-d]imidazol-4-one |
NA |
NA |
NA |
114000 |
NA |
NA |
TTD |
| TLR7 |
(1)Benzopyrano(3,4-d)imidazol-4(1H)-one, 1-butyl- |
NA |
NA |
NA |
107000 |
NA |
NA |
TTD |
| TLR7 |
Methyl 4-amino-1-(2-hydroxy-2-methylpropyl)imidazo[4,5-c]quinoline-7-carboxylate |
NA |
NA |
NA |
270000 |
NA |
NA |
TTD |