| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TNF |
3-(4-Cyano-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionamide |
NA |
150000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TNF |
3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(3-methoxy-phenyl)-propionamide |
NA |
120000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TNKS2 |
2-(3-phenylmethoxyphenyl)-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one |
NA |
230000 |
NA |
NA |
NA |
NA |
TTD |
| TNKS2 |
2-(2-chlorophenyl)-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one |
NA |
140000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
6-(1-Hydroxy-butyl)-5,8-dimethoxy-[1,4]naphthoquinone |
NA |
129700 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
[(1R)-1-(5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enyl] (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoate |
NA |
625000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-glucopyranosyl]-7-O-alpha-L-rhamnopyranoside |
NA |
220000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
(3E)-3-benzylidene-1-benzofuran-2-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
(3E)-3-[(3-hydroxy-4-methoxyphenyl)methylidene]-1-benzofuran-2-one |
NA |
800000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
Ginsenoside Rd |
NA |
250000 |
NA |
NA |
NA |
NA |
PubChem|TTD |
| TOP1 |
20(S)-Ginsenoside Rg2 |
NA |
250000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
Ginsenoside Rb3 |
NA |
250000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
7-(2-Aminoethylamino)-6-fluoro-8-methoxy-4-oxo-1-[(4-phenylphenyl)methyl]quinoline-3-carboxylic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
6-Fluoro-8-methoxy-7-[2-(methylamino)ethylamino]-4-oxo-1-[(4-phenylphenyl)methyl]quinoline-3-carboxylic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
6-Fluoro-8-methoxy-7-[3-(methylamino)propylamino]-4-oxo-1-[(4-phenylphenyl)methyl]quinoline-3-carboxylic acid |
NA |
101000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
6-fluoro-8-methoxy-7-[(3S)-3-(methylaminomethyl)pyrrolidin-1-yl]-4-oxo-1-[(4-phenylphenyl)methyl]quinoline-3-carboxylic acid |
NA |
154600 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
6-Fluoro-7-[2-(methylamino)ethylamino]-4-oxo-1-[(4-phenylphenyl)methyl]quinoline-3-carboxylic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-fluoro-8-methoxy-4-oxo-1-[(4-phenylphenyl)methyl]quinoline-3-carboxamide |
NA |
184200 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
6-Fluoro-8-methoxy-7-[4-(methylamino)butylamino]-4-oxo-1-[(4-phenylphenyl)methyl]quinoline-3-carboxylic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-fluoro-8-methoxy-4-oxo-1-[(4-pyrazol-1-ylphenyl)methyl]quinoline-3-carboxylic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |