| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TOP1 |
7-[(3R)-3-carbamoylpyrrolidin-1-yl]-6-fluoro-8-methoxy-4-oxo-1-[(4-phenylphenyl)methyl]quinoline-3-carboxylic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
6-fluoro-7-[(3R)-3-(hydroxymethyl)pyrrolidin-1-yl]-8-methoxy-4-oxo-1-[(4-phenylphenyl)methyl]quinoline-3-carboxylic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
6H-Purin-6-one, 2-((3,4-dichlorophenyl)amino)-1,9-dihydro- |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
6-(1-Hydroxy-ethyl)-5,8-dimethoxy-[1,4]naphthoquinone |
NA |
110630 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
3-O-Beta-D-Glucopyranosyl Quinovic Acid |
NA |
250000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
(1S,2R,4aS,6aR,6bR,8aR,10S,12aR,12bR,14bS)-1,2,6b,9,9,12a-hexamethyl-10-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-4a-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)carbonyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-6a-carboxylic acid |
NA |
250000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
(3E)-3-[(4-nitrophenyl)methylidene]-1-benzofuran-2-one |
NA |
120000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
6-fluoro-4-oxo-1-[(4-pyrazol-1-ylphenyl)methyl]-7-[[(3R)-pyrrolidin-3-yl]methylamino]quinoline-3-carboxylic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
6-fluoro-7-[(3S)-3-(methylaminomethyl)pyrrolidin-1-yl]-4-oxo-1-[(4-pyrazol-1-ylphenyl)methyl]quinoline-3-carboxylic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
6-fluoro-7-[(3S)-3-(methylaminomethyl)pyrrolidin-1-yl]-4-oxo-1-[(4-phenylphenyl)methyl]quinoline-3-carboxylic acid |
NA |
167600 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
6-fluoro-4-oxo-1-[(4-phenylphenyl)methyl]-7-[[(3S)-pyrrolidin-3-yl]methylamino]quinoline-3-carboxylic acid |
NA |
100400 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
6-fluoro-4-oxo-1-[(4-phenylphenyl)methyl]-7-[[(3R)-pyrrolidin-3-yl]methylamino]quinoline-3-carboxylic acid |
NA |
103900 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-fluoro-4-oxo-1-[1-(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)ethyl]quinoline-3-carboxylic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
6-fluoro-4-oxo-1-[(4-pyrazol-1-ylphenyl)methyl]-7-[[(3S)-pyrrolidin-3-yl]methylamino]quinoline-3-carboxylic acid |
NA |
187400 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-fluoro-8-methoxy-4-oxo-1-[(3-phenyl-1,2-oxazol-5-yl)methyl]quinoline-3-carboxylic acid |
NA |
178400 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
(3E)-5-hydroxy-3-[(4-hydroxyphenyl)methylidene]-1-benzofuran-2-one |
NA |
555000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
7-(2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl)-6-fluoro-4-oxo-1-[(4-pyrazol-1-ylphenyl)methyl]quinoline-3-carboxylic acid |
NA |
172500 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-fluoro-4-oxo-1-[(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)methyl]quinoline-3-carboxylic acid |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
(3E)-3-[(4-methoxyphenyl)methylidene]-1-benzofuran-2-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP1 |
kaempferol 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside |
NA |
110000 |
NA |
NA |
NA |
NA |
TTD |