| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TOP2A |
Benzyl 2-hydroxy-6-pentyl-4-[2-pentyl-4,6-bis(phenylmethoxy)benzoyl]oxybenzoate |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
4-(2,4-Dihydroxybenzoyl)oxy-2-hydroxy-6-pentylbenzoic acid |
NA |
250000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
(2,2-Dimethyl-4-oxo-5-pentyl-1,3-benzodioxin-7-yl) 2,4-dihydroxy-6-pentylbenzoate |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
1-[[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethane-1,2-diol |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
Benzyl 4-[2,4-bis(phenylmethoxy)benzoyl]oxy-2-hydroxybenzoate |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
Decarboxyanziaic acid |
NA |
250000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
4-(2,4-Dihydroxy-6-pentylbenzoyl)oxy-2-hydroxybenzoic acid |
NA |
125000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
prop-2-ynyl N-[[3-(ethylcarbamoylamino)-5-(2-methylpyridin-4-yl)isoquinolin-8-yl]methyl]carbamate |
NA |
256000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
(2R,4S,4aS)-11-Fluoro-2,4-dimethyl-8-(2-oxo-1,3-oxazolidin-3-yl)-1,2,4,4a-tetrahydro-2'H,6H-spiro[1,4-oxazino[4,3-a][1,2]oxazolo[4,5-g]quinoline-5,5'-pyrimidine]-2',4',6'(1'H,3'H)-trione |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
6-[(1-cyclopentyltetrazol-5-yl)sulfanylmethyl]-2-N-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
2-[(3S,10R,13R,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethanol |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
6-Hydroxy-3-[1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-3H-benzofuran-2-one |
NA |
400000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
(2-(Diethylamino)ethy]-9-methoxy-2H-[1]-benzothiopyrano[4,3,2-cd]indazole-5-methanamine |
NA |
NA |
NA |
260000 |
NA |
NA |
TTD |
| TOP2A |
Ginsenoside Rb1 |
NA |
250000 |
NA |
NA |
NA |
NA |
PubChem|TTD |
| TOP2A |
Formamide, N-((1-((2-(diethylamino)ethyl)amino)-7-methoxy-9-oxo-9H-thioxanthen-4-yl)methyl)- |
NA |
NA |
NA |
480000 |
NA |
NA |
TTD |
| TOP2A |
Ginsenoside F2 |
NA |
250000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2A |
Ginsenoside Rg3 |
NA |
250000 |
NA |
NA |
NA |
NA |
PubChem|TTD |
| TOP2A |
methyl N-[[1-[[2-(diethylamino)ethyl]amino]-7-methoxy-9-oxothioxanthen-4-yl]methyl]carbamate |
NA |
NA |
NA |
220000 |
NA |
NA |
TTD |
| TOP2B |
N-[[14-[2-(diethylamino)ethyl]-4-methoxy-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-10-yl]methyl]methanesulfonamide |
NA |
NA |
NA |
210000 |
NA |
NA |
TTD |
| TOP2B |
CID 10068583 |
NA |
NA |
NA |
260000 |
NA |
NA |
TTD |