| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TOP2B |
(2R)-6-(2,6-dimethylpyridin-4-yl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid |
NA |
NA |
NA |
540000 |
NA |
NA |
TTD |
| TOP2B |
(2S)-6-(2,6-dimethylpyridin-4-yl)-2-ethyl-7-fluoro-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid |
NA |
NA |
NA |
420000 |
NA |
NA |
TTD |
| TOP2B |
7-(2,6-Dimethylpyridin-4-yl)-6,8-difluoro-1-(4-fluorophenyl)-4-oxoquinoline-3-carboxylic acid |
NA |
NA |
NA |
430000 |
NA |
NA |
TTD |
| TOP2B |
7-(2,6-Dimethylpyridin-4-yl)-1-ethyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acid |
NA |
NA |
NA |
110000 |
NA |
NA |
TTD |
| TOP2B |
7-(2,6-Dimethylpyridin-4-yl)-6,8-difluoro-1-(2-fluoroethyl)-4-oxoquinoline-3-carboxylic acid |
NA |
NA |
NA |
530000 |
NA |
NA |
TTD |
| TOP2B |
7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxo-1H-quinoline-3-carboxylic acid |
NA |
NA |
NA |
300000 |
NA |
NA |
TTD |
| TOP2B |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-2-methyl-4-oxoquinoline-3-carboxylic acid |
NA |
NA |
NA |
260000 |
NA |
NA |
TTD |
| TOP2B |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxo-2-phenylquinoline-3-carboxylic acid |
NA |
NA |
NA |
220000 |
NA |
NA |
TTD |
| TOP2B |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-2-phenylquinolin-4-one |
NA |
NA |
NA |
240000 |
NA |
NA |
TTD |
| TOP2B |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxo-5-phenylsulfanylquinoline-3-carboxylic acid |
NA |
NA |
NA |
420000 |
NA |
NA |
TTD |
| TOP2B |
[(2R,4aR,6R,7R,8R,8aS)-6-[[(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-5-yl]oxy]-7-[[2-[(5-fluoro-1,3-benzothiazol-2-yl)sulfanyl]acetyl]amino]-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-yl] 2-[(5-fluoro-1,3-benzothiazol-2-yl)sulfanyl]acetate |
NA |
116500 |
NA |
NA |
NA |
NA |
TTD |
| TOP2B |
[(2R,4aR,6R,7R,8R,8aS)-6-[[(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-5-yl]oxy]-7-[[2-[(5-fluoro-1,3-benzoxazol-2-yl)sulfanyl]acetyl]amino]-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-yl] 2-[(5-fluoro-1,3-benzoxazol-2-yl)sulfanyl]acetate |
NA |
124200 |
NA |
NA |
NA |
NA |
TTD |
| TOP2B |
(-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, hemihydrate |
NA |
NA |
NA |
280000 |
NA |
NA |
PubChem |
| TOP2B |
Nalidixic Acid |
NA |
223000 |
NA |
NA |
NA |
NA |
BindingDB |
| TOP2B |
2-[[1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxoquinolin-3-yl]methyl]benzoic acid |
NA |
NA |
NA |
200000 |
NA |
NA |
TTD |
| TOP2B |
3-(Cyclohexylmethyl)-1-cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoroquinolin-4-one |
NA |
NA |
NA |
230000 |
NA |
NA |
TTD |
| TOP2B |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-3-(naphthalen-1-ylmethyl)quinolin-4-one |
NA |
NA |
NA |
210000 |
NA |
NA |
TTD |
| TOP2B |
1-Cyclopropyl-3-[[4-(dimethylamino)phenyl]methyl]-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoroquinolin-4-one |
NA |
NA |
NA |
210000 |
NA |
NA |
TTD |
| TOP2B |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-3-phenylquinolin-4-one |
NA |
NA |
NA |
120000 |
NA |
NA |
TTD |
| TOP2B |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-3-(2-phenylethyl)quinolin-4-one |
NA |
NA |
NA |
120000 |
NA |
NA |
TTD |